{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:06:25Z","timestamp":1788573985434,"version":"build-2803163510"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Oral submucous fibrosis (OSF) is a potentially malignant disorder characterised by inflammation and progressive fibrosis. Transforming growth factor-\u03b2 (TGF-\u03b2) has been established as a master regulator of fibrosis in various organs; however, lack of systematic review on expression of TGF-\u03b2 and its isoforms in OSF restrict the understanding of their behaviour in its pathogenesis. Online electronic databases, such as PubMed Medline, Cochrane Library, Embase, and Scopus, were searched from their respective dates of inception till 31st March 2022. Human studies related to TGF-\u03b2 expression in histopathologically diagnosed OSF cases, with or without malignant transformation, were included and assessed using a Cochrane risk of bias assessment tool: For non randomised studies of interventions (ACROBAT NRSI). The electronic literature search yielded 394 articles. Of those, ten articles met the inclusion criteria and involved total of 579 OSF patients. The risk of bias (RoB) was low to moderate. These studies demonstrated a significant positive expression of TGF-\u03b2 and its isoforms in OSF compared to that in normal tissue samples. An increased pan TGF-\u03b2 expression was observed in the early stages of OSF, and an increased expression of TGF-\u03b21 and TGF-\u03b22 were seen in advanced stages of OSF. Stage wise expression of TGF-\u03b23 has not been discussed in the included studies. No significant relationship was observed between epithelial dysplasia and TGF-\u03b2 expression in OSF. The distinct pattern in the expression of pan TGF-\u03b2, TGF-\u03b21 and TGF-\u03b22 in various stages of OSF indicates their different roles in OSF progression. We believe isoform targeted studies exploring stage wise expression of the marker will open new treatment avenues for OSF.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_536_22","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T20:20:04Z","timestamp":1725654004000},"page":"348-358","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Expression of transforming growth factor-\u03b2 in oral submucous fibrosis: A systematic review"],"prefix":"10.4103","volume":"27","author":[{"given":"Shivani P.","family":"Bansal","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Treville","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, School of Dentistry, D. Y. 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