{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:43Z","timestamp":1786650043814,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Dental caries is prevalent in spite of widespread use of mechanical and chemical plaque control methods. Streptococcus mutans is said to have a strong background in initiation of dental caries. Hence, exceptional methods are required which would be effective against dental caries. Current era is taking people back to traditional or herbal medicine, which is said to have comparatively better healing effects than synthetic drugs in the market.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Determine and analyse the minimum zone of inhibition of Curcuma amada against Streptococcus mutans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>\n                      An\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      Study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods, Statistical Analysis Used:<\/jats:title>\n                    <jats:p>The well diffusion method using blood agar plates was used to evaluate the antibacterial activity of 5%, 10% and 25% concentration of C. Amada extract against Streptococcus mutans in comparison with 0.2% chlorhexidine. Results were statistically analysed using independent sample t-test or Mann\u2013Whitney U test to compare mean or median zone of inhibition between two groups. Thus, the zone of inhibition (in mm) was analysed using the mean of all the readings obtained and the level of significance at &lt;0.05 was considered statistically significant at 5% of level of significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Maximum zone of inhibition was found to be with C. amada compared to corresponding concentration of 0.2% chlorhexidine. Thus, inhibitory effect of C. amada is significantly better than 5%, 10% and 25% chlorhexidine mouthwash. The inhibitory effect increases as the concentration increases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The antibacterial activity of C. amada against Streptococcus mutans raises the possibility of incorporating it in various dental therapeutic agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_551_22","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T20:21:08Z","timestamp":1725654068000},"page":"302-306","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Antimicrobial activity of Curcuma amada extract on Streptococcus mutans\u2014An in vitro study"],"prefix":"10.4103","volume":"27","author":[{"given":"Jessica J","family":"Maria","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karpagaselvi","family":"Karuppiah","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheen","family":"Shariff","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneek","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"R1-20240906","first-page":"369","article-title":"[An adaptation of A Textbook of Oral Pathology, 1983, 4e, Elsevier Inc]","author":"Sivapathasundharam","year":"2020","journal-title":"Shafer's Textbook of Oral Pathology"},{"key":"R2-20240906","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4103\/jispcd.JISPCD_42_21","article-title":"Prevalence of dental caries in the Indian population: A systematic review and meta-analysis","volume":"11","author":"Pandey","year":"2021","journal-title":"J Int Soc Prev Community Dent"},{"key":"R3-20240906","first-page":"270","article-title":"Chlorhexidine: The gold standard antiplaque agent","volume":"5","author":"Balagopal","year":"2013","journal-title":"J Pharm Sci Res"},{"key":"R4-20240906","first-page":"133","article-title":"Use of herbs and medicinal plants in dentistry: A 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activities","volume":"36","author":"Policegoudra","year":"2011","journal-title":"J Biosci"},{"key":"R8-20240906","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4103\/2319-5932.171159","article-title":"Antimicrobial effectiveness of Neem (Azadirachta indica) and Babool (Acacia nilotica) on Streptococcus mutans: An in vitro study.","volume":"13","author":"Sajankumar","year":"2015","journal-title":"J Indian Assoc Public Health Dent"},{"key":"R9-20240906","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.5005\/jp-journals-10024-2165","article-title":"Antimicrobial effect of ginger, garlic, honey, and lemon extracts on streptococcus mutans","volume":"18","author":"Mathai","year":"2017","journal-title":"J Contemp Dent Pract"},{"key":"R10-20240906","doi-asserted-by":"crossref","first-page":"489842","DOI":"10.1155\/2015\/489842","article-title":"In vitro effect of zingiber officinale extract on growth of streptococcus mutans and streptococcus sanguinis","volume":"2015","author":"Azizi","year":"2015","journal-title":"Int J Dent"},{"key":"R11-20240906","doi-asserted-by":"crossref","first-page":"94","DOI":"10.22159\/ajpcr.2018.v11s2.28591","article-title":"Comparative assessment of in vitro antimicrobial activity of Curcuma caesia Roxb. and Curcuma amada Roxb.","volume":"11","author":"Kaur","year":"2018","journal-title":"Asian J Pharm Clin Res"},{"key":"R12-20240906","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.26452\/ijrps.v11i3.2510","article-title":"Phytochemical and pharmacological properties of curcuma amada: A review","volume":"11","author":"Mahadevi","year":"2020","journal-title":"Int J Res Pharm Sci"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_551_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:23Z","timestamp":1786647683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_551_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_551_22","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2022-12-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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