{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:30:51Z","timestamp":1787070651882,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is the third most common head and neck malignancy, with tongue squamous cell carcinoma (TSCC) being highly aggressive due to its vascular and lymphatic supply. This study examines the correlation between the worst pattern of invasion (WPOI) and Ki-67 expression in TSCC to improve prognosis and treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis of 51 TSCC specimens (2021\u20132024) assessed clinicopathological data, WPOI classification, and Ki-67 expression using immunohistochemistry. Statistical correlations were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study showed a male predominance (mean age 53 years), with non-healing ulcers on the lateral tongue as the most common presentation. High-risk WPOI patterns correlated with advanced disease and metastasis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Ki-67 expression averaged 45% in aggressive cases, but no significant correlation was found between WPOI and extranodal extension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>WPOI and Ki-67 are crucial markers for TSCC aggressiveness, aiding in risk stratification and personalized treatment. Further validation in larger cohorts is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_6_25","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T02:00:22Z","timestamp":1751248822000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Correlation of the WPOI and clinicopathological parameters in tongue OSCC patients"],"prefix":"10.4103","volume":"29","author":[{"given":"Priyadharshini","family":"Muthumanickam","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheena","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Saveetha Dental College and Hospitals, 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