{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:33Z","timestamp":1787840313578,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This case report presents a rare benign salivary gland tumour called sialadenoma papilliferum. It comprises 3 to 5% of head and neck tumours and about 1% of all minor salivary gland tumours. The focus is on discussing the BRAFV600E mutation analysis and exploring its clinical implications, along with delving into the histopathological differentials. We documented a 73-year-old male, who had a white patch in the left retromolar trigone region for 6 months. The tumour was excised with a clinical diagnosis of verrucous lesion. Microscopic examination revealed exophytic hyperplastic parakeratotic stratified squamous epithelium and endophytic ductal papillary proliferation. The BRAFV600E mutation was present in the patient. Subsequent regular follow-ups were conducted, revealing no recurrence of the condition. This case underscores the pivotal role of BRAFV600E analysis as an invaluable diagnostic tool when confronted with the intricacies of intraoral salivary gland neoplasms.<\/jats:p>","DOI":"10.4103\/jomfp.jomfp_72_24","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:01:04Z","timestamp":1728957664000},"page":"488-492","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Mutational analysis of BRAFV600E in a case of sialadenoma papilliferum of oral cavity"],"prefix":"10.4103","volume":"28","author":[{"given":"Kiran","family":"Jot","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reddipalli","family":"Sharath","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ongkila","family":"Bhutia","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Surya","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"R1-20241016","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13000-021-01084-5","article-title":"Sialadenoma papilliferum: Clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature","volume":"16","author":"Chen","year":"2021","journal-title":"Diagn Pathol"},{"key":"R2-20241016","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.path.2020.09.006","article-title":"Sialadenoma papilliferum","volume":"14","author":"Hsieh","year":"2021","journal-title":"Surg Pathol Clin"},{"key":"R3-20241016","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/1097-0142(196911)24:5<1057::AID-CNCR2820240529>3.0.CO;2-L","article-title":"Sialadenoma papilliferum. A previously unreported salivary gland tumor","volume":"24","author":"Abrams","year":"1969","journal-title":"Cancer"},{"key":"R4-20241016","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12105-019-01068-4","article-title":"Salivary Sialadenoma Papilliferum Consists of Two Morphologically, Immunophenotypically, and Genetically Distinct Subtypes","volume":"14","author":"Hsieh","year":"2020","journal-title":"Head Neck Pathol"},{"key":"R5-20241016","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/his.13990","article-title":"Histopathological evaluation of minor salivary gland papillary-cystic tumours: Focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm","volume":"76","author":"Nakaguro","year":"2020","journal-title":"Histopathology"},{"key":"R6-20241016","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1038\/jid.2015.180","article-title":"Somatic V600E BRAF mutation in linear and sporadic syringocystadenoma papilliferum","volume":"135","author":"Levinsohn","year":"2015","journal-title":"J Invest Dermatol"},{"key":"R7-20241016","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1067\/moe.2001.115978","article-title":"Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature","volume":"92","author":"Brannon","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-20241016","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12105-017-0852-8","article-title":"Sialadenoma papilliferum: Analysis of seven new cases and review of the literature","volume":"12","author":"Fowler","year":"2018","journal-title":"Head Neck Pathol"},{"key":"R9-20241016","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0278-2391(97)90078-1","article-title":"Sialadenoma papilliferum of the hard palate: A case report and review of literature","volume":"55","author":"Asahina","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"R10-20241016","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1177\/10668969221147170","article-title":"Clinicopathologic study of sialadenoma papilliferum of the minor salivary glands: A series of 8 new cases with BRAF V600E mutation-specific immunohistochemical analysis","volume":"31","author":"Owosho","year":"2023","journal-title":"Int J Surg Pathol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_72_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:05Z","timestamp":1787836805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_72_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_72_24","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-03-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}