{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:08Z","timestamp":1786653728659,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Oral submucous fibrosis (OSF) is a potentially malignant disorder of oral cavity. The vascularity of submucosa in this disease can predict its malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In this study, attempts have been made to investigate different parameters of vascularity, such as mean vascular area, luminal diameter etc., in advanced OSF and make a comparison with malignancy associated with OSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Incisional biopsy was taken from clinically diagnosed cases of advanced OSF and malignancy associated with OSF. Sections were prepared and stained with haematoxylin and eosin for histomorphometric analysis using a research microscope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A statistically significant increase in mean vascular area and luminal diameter of blood vessels was noticed in malignancy associated with OSF compared to advanced OSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>To support the nutritional demand of carcinogenesis, increased blood supply is required; hence blood supply increased in the form of budding blood vessels or enlarged dilated blood vessels. These changes can be used as a predictive marker for this transformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_89_24","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T12:28:45Z","timestamp":1743337725000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of blood vessel morphometry in advanced oral submucous fibrosis and malignancy associated with oral submucous fibrosis"],"prefix":"10.4103","volume":"29","author":[{"given":"Tathagata","family":"Bhattacharjee","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supratim","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Dentistry, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipto","family":"De","sequence":"additional","affiliation":[{"name":"Department of Dental, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Dr. R. 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