{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:54Z","timestamp":1786649874313,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Oral submucous fibrosis (OSF) is a progressive potentially malignant disorder. Matrix metalloproteinase-3 (\n                    <jats:italic toggle=\"yes\">MMP3<\/jats:italic>\n                    ) regulates extracellular matrix remodelling, and promoter polymorphisms may influence OSF susceptibility. This systematic review and meta-analysis evaluated the association between\n                    <jats:italic toggle=\"yes\">MMP3<\/jats:italic>\n                    expression, promoter polymorphism, and OSF risk. Electronic databases (PubMed, Cochrane, Google Scholar, ScienceDirect) were searched for studies published between 2000 and 2023, assessing\n                    <jats:italic toggle=\"yes\">MMP3<\/jats:italic>\n                    expression or promoter polymorphism in OSF. Four eligible studies were analysed using RevMan 5.4. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using I\u00b2 statistics, and publication bias using funnel plot asymmetry and Egger\u2019s test. No significant association was observed between OSF risk and the homozygous 5A\/5A genotype (OR = 2.34, 95% CI 0.63\u20138.71,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.21, I\u00b2 = 0%) or homozygous 6A\/6A genotype (OR = 1.23, 95% CI 0.20\u20137.56,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.83, I\u00b2 = 89%). The heterozygous 5A\/6A genotype showed a significant association with increased OSF susceptibility (OR = 2.75, 95% CI 1.63\u20134.64,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.0002, I\u00b2 = 0%). Egger\u2019s test indicated no publication bias. All studies demonstrated acceptable methodological quality. The\n                    <jats:italic toggle=\"yes\">MMP3<\/jats:italic>\n                    -1171 5A\/6A promoter polymorphism is significantly associated with nearly three-fold increased OSF risk, whereas homozygous genotypes show no significant association. These findings suggest a role of\n                    <jats:italic toggle=\"yes\">MMP3<\/jats:italic>\n                    promoter variation in OSF pathogenesis. Larger, well-designed studies are required to validate these results and assess their diagnostic and preventive value.\n                  <\/jats:p>","DOI":"10.4103\/jomfp.jomfp_90_25","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:00:34Z","timestamp":1766836834000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Matrix metalloproteinases-3 gene-promoter polymorphism as a risk factor in oral submucous fibrosis: A systematic review and meta-analysis"],"prefix":"10.4103","volume":"29","author":[{"given":"Dipak D.","family":"Ghatage","sequence":"first","affiliation":[{"name":"Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay A.","family":"Dhobley","sequence":"additional","affiliation":[{"name":"Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra H.","family":"Palve","sequence":"additional","affiliation":[{"name":"Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini G.","family":"Kendre","sequence":"additional","affiliation":[{"name":"Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya V.","family":"Ghodichor","sequence":"additional","affiliation":[{"name":"Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil V.","family":"Lakavath","sequence":"additional","affiliation":[{"name":"Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J Biol Chem"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1096\/fasebj.12.12.1075","article-title":"Matrix metalloproteinases: Structures, evolution, and diversification","volume":"12","author":"Massova","year":"1998","journal-title":"FASEB J"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejim.2007.01.007","article-title":"The role of matrix metalloproteinases in acute coronary syndromes","volume":"18","author":"Dabek","year":"2007","journal-title":"Eur J Intern Med"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1601-0825.2004.01038.x","article-title":"Matrix metalloproteinases in oral diseases","volume":"10","author":"Sorsa","year":"2004","journal-title":"Oral Dis"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1158\/0008-5472.CAN-04-0910","article-title":"A protective role for matrix metalloproteinase-3 in squamous cell carcinoma","volume":"64","author":"McCawley","year":"2004","journal-title":"Cancer Res"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/08959374940080022701","article-title":"Connective tissue degradation in periodontal disease: Role of matrix metalloproteinases and inhibitors","volume":"8","author":"Reynolds","year":"1994","journal-title":"Adv Dent 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upregulation of MMP-1 in oral carcinoma","volume":"53","author":"Lee","year":"2008","journal-title":"Arch Oral Biol"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bjoms.2012.08.014","article-title":"Oral submucous fibrosis: Etiology, pathogenesis and management","volume":"51","author":"Arakeri","year":"2013","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R13-20260420","first-page":"39","article-title":"Oral submucous fibrosis: Current concepts","volume":"1","author":"Gupta","year":"2008","journal-title":"Peoples J Sci Res"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.oraloncology.2005.07.008","article-title":"Promoter polymorphisms of MMP-2 and TIMP-2 in head and neck cancer","volume":"42","author":"O-Charoenrat","year":"2006","journal-title":"Oral Oncol"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.oraloncology.2008.05.003","article-title":"Gene polymorphisms and oral cancer risk","volume":"45","author":"Vairaktaris","year":"2009","journal-title":"Oral Oncol"},{"key":"R16-20260420","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1423-0127-17-10","article-title":"MMP and TIMP polymorphisms in head and neck lesions","volume":"17","author":"Chaudhary","year":"2010","journal-title":"J Biomed Sci"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ajo.2006.03.063","article-title":"MMP3 and TIMP1 genes in high myopia","volume":"142","author":"Liang","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"R18-20260420","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0714.2006.00370.x","article-title":"MMP3 polymorphism as a risk factor for oral submucous fibrosis","volume":"35","author":"Tu","year":"2006","journal-title":"J Oral Pathol 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Dent"},{"key":"R23-20260420","first-page":"2992","article-title":"MMP1 polymorphism and cancer risk: Meta-analysis","volume":"7","author":"Han","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"R24-20260420","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1368-8375(03)00101-5","article-title":"TIMP-1 expression induced by arecoline and safrole","volume":"39","author":"Shieh","year":"2003","journal-title":"Oral Oncol"},{"key":"R25-20260420","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1368-8375(01)00045-8","article-title":"Arecoline increases TIMP-1 in buccal fibroblasts","volume":"38","author":"Chang","year":"2002","journal-title":"Oral Oncol"},{"key":"R26-20260420","first-page":"159","article-title":"Oral submucous fibrosis and iron deficiency","volume":"2","author":"Rupak","year":"2012","journal-title":"E-J Dent"},{"key":"R27-20260420","first-page":"181","article-title":"Placental extract in oral submucous fibrosis","volume":"24","author":"Katharia","year":"1992","journal-title":"Indian J Pharmacol"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_90_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:23Z","timestamp":1786647563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_90_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_90_25","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}