{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:47Z","timestamp":1787761727099,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Granulomatosis with polyangiitis (GPA) is a rare multisystem disease characterized by a triad of necrotizing granulomas affecting the upper and lower respiratory tract, vasculitis and glomerulonephritis. Oral lesions are seen in 6\u201313% of cases, although not life threatening but might be the first symptoms reported by the patient. Here we present a case of gingival growth, later diagnosed as GPA owing to the timely recognition by the dentist. A 33-year-old female reported for evaluation of soft tissue growth in her lower left back tooth region present for past 3 months. She had no relevant medical or family history. Clinically it looked like a benign hypertrophic gingival enlargement. The histopathological picture was suggestive of vasculitis and nonspecific granuloma formation. On further examination altered Renal Function Test and cavitating granulomas were noted in her lungs along with a positive cytoplasmic ANCA (c-ANCA) test which led to the diagnosis of GPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_92_22","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:21:23Z","timestamp":1682486483000},"page":"425","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Role of a dentist in early diagnosis of Granulomatosis with Polyangiitis"],"prefix":"10.4103","volume":"26","author":[{"given":"Hajira","family":"Khatoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N S","family":"Sahana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Renuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-36-20240906","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1590\/abd1806-4841.20153455","article-title":"Granulomatosis with polyangiitis, a new nomenclature for Wegener's granulomatosis-Case report","volume":"90","author":"Lima","year":"2015","journal-title":"An Bras Dermatol"},{"key":"R2-36-20240906","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10157-013-0869-6","article-title":"Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides","volume":"17","author":"Jennette","year":"2013","journal-title":"Clin Exp 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radiological assessment","volume":"14","author":"Szczeklik","year":"2019","journal-title":"J Dent Sci"},{"key":"R7-36-20240906","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tripleo.2005.04.018","article-title":"Wegener's granulomatosis: The current understanding","volume":"100","author":"Ponniah","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-36-20240906","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/adj.12441","article-title":"Gingival granulomatosis with polyangiitis (Wegener's granulomatosis) as a primary manifestation of the disease","volume":"62","author":"Fonseca","year":"2017","journal-title":"Aust Dent J"},{"key":"R9-36-20240906","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/jop.12030","article-title":"Wegener's granulomatosis a review of clinical features and an update in diagnosis and treatment","volume":"42","author":"Almouhawis","year":"2013","journal-title":"J Oral Pathol Med"},{"key":"R10-36-20240906","doi-asserted-by":"crossref","first-page":"338","DOI":"10.14219\/jada.archive.2007.0166","article-title":"Oral manifestations of Wegener's granulomatosis: A report of three cases and a literature review","volume":"138","author":"Stewart","year":"2007","journal-title":"J Am Dent Assoc"},{"key":"R11-36-20240906","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/ar98","article-title":"What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis","volume":"2","author":"Clayton","year":"2000","journal-title":"Arthritis Res Ther"},{"key":"R12-36-20240906","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-pathol-011811-132453","article-title":"Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis","volume":"8","author":"Jennette","year":"2013","journal-title":"Annu Rev 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Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_92_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:04:07Z","timestamp":1787760247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jomfp.jomfp_92_22"}},"subtitle":["A rare case report"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jomfp.jomfp_92_22","relation":{},"ISSN":["0973-029X"],"issn-type":[{"value":"0973-029X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}