{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:52Z","timestamp":1786649872285,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Elevated IgG levels signify immune activation during the transition from OSMF to OSCC. Integrating IgG profiling with molecular diagnostics enhances early detection, risk prediction, and personalized treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim is to estimate and evaluate the serum immunoglobulin G (IgG) levels in OSMF and OSCC patients and compare them with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>Sardar Patel Postgraduate Institute of Dental and Medical Sciences Cross-sectional, Observational, Quantitative Study<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>This study involved 36 participants aged 18 and older. After informed consent and oral examination, 2 mL blood samples were drawn, processed, and serum separated. Serum IgG levels were measured using Nephelometry (AGAPPE MISPA i2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical analysis used:<\/jats:title>\n                    <jats:p>Statistical analysis was performed using the Chi-square test and ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean serum IgG levels were highest in the OSCC group (1606.86 \u00b1 500.44 mg\/dL), followed by the OSMF group (1217.06 \u00b1 136.95 mg\/dL), and lowest in the control group (1113.58 \u00b1 88.92 mg\/dL). One-way ANOVA demonstrated a statistically significant difference in mean IgG levels among the three groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00087), indicating a progressive elevation of IgG with disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>IgG levels were highest in OSCC, with a positive correlation to OSMF severity, suggesting its potential as a biomarker. Age, gender, and lifestyle factors significantly influenced disease onset and progression across the studied groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jomfp.jomfp_94_25","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:00:12Z","timestamp":1766836812000},"page":"550-556","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin G (IgG) in oral submucous fibrosis and oral squamous cell carcinoma \u2013 An ex vivo study"],"prefix":"10.4103","volume":"29","author":[{"given":"Aanchal","family":"Tandon","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, Career Institute of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Khare","sequence":"additional","affiliation":[{"name":"Department of Oral and 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