{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:50Z","timestamp":1787169710984,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n OBJECTIVE:<\/jats:title>\n This study aimed to evaluate the effect of the local injection of injectable platelet-rich fibrin (i-PRF) on the eruption rate of the teeth and evaluation of the effect of i-PRF on the number of odontoblast, cementoblast, osteoblast, osteocyte, and osteoclast cells.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n The samples consisted of 20 male albino rabbits and were divided randomly into the control group (5 rabbits) and i-PRF groups (15 rabbits) sub-divided into week 1, week 2, and week 3 sub-groups. The labial surface of lower right incisors was marked by drilling a hole at the level of the free gingival margin in the mid-line of each tooth with a small round bur, and the eruption rates were measured by measuring the distance from the most apical point of the free gingival margin and the center of the hole with a digital caliper. i-PRF was prepared by centrifuging autologous blood of each rabbit at 1000 rpm for 5 minutes; then the i-PRF layer was collected. The control group received no treatment, whereas i-PRF groups received i-PRF in the following manner: For week 1 groups, a single dose was given at 0 day; for week 2 groups, double doses were given at 0 and 7 days; and for week 3 groups, three doses were given at 0, 7, and 14 days. At the end of experiments for each group, animal scarification was performed, and histological steps were performed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n There was a significant increase in the rate of tooth eruption in i-PRF groups when compared to the control group, and the eruption rate was increased in 107.3%, 144.7%, and 167.5% for week 1, week 2, and week 3, respectively. Concerning the histological finding, the i-PRF groups gave rise to a higher number of odontoblast, cementoblast, osteoblast, osteocyte, and osteoclast cells with a significant difference when compared to the control groups (\n P<\/jats:italic>\n \u2264 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Applying i-PRF significantly increased the rate of teeth eruption at all-time intervals. Platelet-rich fibrin injection can be an effective method for acceleration of teeth eruption.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jos.jos_109_22","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:08:51Z","timestamp":1694045331000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of local injection of injectable platelet-rich fibrin on eruption rate of teeth (Rabbit animal model)"],"prefix":"10.4103","volume":"12","author":[{"given":"Enas Talb","family":"Al-Jwary","sequence":"first","affiliation":[{"name":"Department of Pedodontic, Orthodontic and Preventive Dentistry, Collage of Dentistry, University of Mosul, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niam Riyadh","family":"Al-Saleem","sequence":"additional","affiliation":[{"name":"Department of Pedodontic, Orthodontic and Preventive Dentistry, Collage of Dentistry, University of Mosul, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"R1-20240830","first-page":"1153","article-title":"The development of the human dentition","volume":"28","author":"Schour","year":"1941","journal-title":"J Am Dent Assoc"},{"key":"R2-20240830","first-page":"81","article-title":"Delayed tooth eruption","volume":"1","author":"Peedikayil","year":"2011","journal-title":"e-J Dent"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1051\/odfen\/2018129","article-title":"Tooth eruption disorders associated with systemic and genetic diseases: Clinical guide","volume":"20","author":"Choukroune","year":"2017","journal-title":"J Dentofacial Anom Orthod"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fdj.2018.05.001","article-title":"Recent advances in understanding theories of eruption (evidence based review article)","volume":"4","author":"Rabea","year":"2018","journal-title":"Future Dent J"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034519882692","article-title":"Mesenchymal progenito regulation of tooth eruption: A view from PTHrP","volume":"99","author":"Nagata","year":"2020","journal-title":"J Dent Res"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1601-6343.2009.01439.x","article-title":"Cellular and molecular basis of tooth eruption","volume":"12","author":"Wise","year":"2009","journal-title":"Orthod Craniofac Res"},{"key":"R8-20240830","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ajodo.2003.10.031","article-title":"Delayed tooth eruption: Pathogenesis, diagnosis, and treatment. 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