{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:39Z","timestamp":1787840679501,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Oral precancerous lesions (OPLs), including leukoplakia, erythroplakia, oral submucous fibrosis (OSMF), and oral lichen planus (OLP), pose a significant risk for malignant transformation into oral squamous cell carcinoma.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To evaluate and analyze the correlation between fasting blood glucose levels and lipid profile parameters in patients with oral precancerous lesions.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This cross-sectional observational study included 110 participants, 80 patients with clinically and histologically diagnosed oral precancerous lesions and 30 age- and gender-matched healthy controls. Fasting blood samples were analyzed for glucose, total cholesterol, triglycerides, LDL, and HDL levels.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Patients with OPLs showed significantly elevated fasting blood glucose (108.3 \u00b1 14.2 mg\/dL), total cholesterol (210.5 \u00b1 28.7 mg\/dL), triglycerides (165.3 \u00b1 33.6 mg\/dL), and LDL (137.2 \u00b1 26.1 mg\/dL), along with reduced HDL levels (36.8 \u00b1 7.2 mg\/dL) compared to controls (\n P<\/jats:italic>\n < 0.001). A significant positive correlation was observed between fasting blood glucose and lipid parameters (cholesterol:\n r<\/jats:italic>\n = 0.52, triglycerides:\n r<\/jats:italic>\n = 0.47, LDL:\n r<\/jats:italic>\n = 0.44), while HDL showed a negative correlation (\n r<\/jats:italic>\n = \u20130.39).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n It is concluded that patients with oral precancerous lesions demonstrate significant metabolic alterations. The correlation between blood glucose and lipid profiles highlights the potential role of systemic metabolic dysregulation in the development and progression of OPLs.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1012_25","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:00:30Z","timestamp":1756486830000},"page":"S2581-S2583","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Lipid Profile and Blood Glucose Levels in Oral Precancerous Lesion"],"prefix":"10.4103","volume":"17","author":[{"given":"Tarang K.","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash C.","family":"Morya","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Government Hospital Kalyanpur, Balotra, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Inderprastha Dental College, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagyodai N.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Alpha Smile Dental Clinic and Implant Centre, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Government Saadat District Hospital, Tonk, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, M. M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"R1-20250930","first-page":"464","article-title":"Lipid profile in oral potentially malignant disorders and oral squamous cell carcinoma \u2013A prognostic view","volume":"26","author":"Sai","year":"2022","journal-title":"J Oral MaxillofacPathol"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12903-023-02859-6","article-title":"Clinical relevance of serum lipids in the carcinogenesis of oral squamous cell carcinoma","volume":"23","author":"Qian","year":"2023","journal-title":"BMC Oral Health"},{"key":"R3-20250930","first-page":"171","article-title":"Alterations in serum lipid profile in oral cancer and oral submucous fibrosis patients: A clinicopathological study","volume":"14","author":"Sangle","year":"2023","journal-title":"Oral MaxillofacPathol J"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/IJDS.IJDS_122_19","article-title":"A comparative study to assess the independency of lipid profile and blood sugar levels as a diagnostic marker in oral cancer and precancerous disorders","volume":"12","author":"Sachdev","year":"2020","journal-title":"Indian J Dent Sci"},{"key":"R5-20250930","doi-asserted-by":"crossref","first-page":"26","DOI":"10.9734\/IBRR\/2015\/14140","article-title":"Lipid profile as a marker of pre-stage cancer and oral cancer in tobacco users","volume":"3","author":"Thabusum","year":"2015","journal-title":"Int Blood Res Rev"},{"key":"R6-20250930","first-page":"119","article-title":"Correlation of lipid profile and glycemia in oral precancerous lesion and conditions","volume":"33","author":"Mujoo","year":"2016","journal-title":"Int J Ther Appl"},{"key":"R7-20250930","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijom.2016.01.015","article-title":"Serum lipid profile in oral squamous cell carcinoma: Alterations and association with some clinicopathological parameters and tobacco use","volume":"45","author":"Acharya","year":"2016","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1012_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:58Z","timestamp":1787837218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1012_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":7,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1012_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2025-06-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}