{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:27Z","timestamp":1787771967679,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Regenerative endodontic procedures (REPs) have emerged as a transformative approach to treating immature permanent teeth with necrotic pulp tissue<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A prospective study was conducted, enrolling 100 patients with immature permanent teeth requiring REPs. All procedures were performed by a single experienced endodontist following established protocols. Patients were followed up for a minimum of 5 years\u2019 post-treatment. Clinical examinations, radiographic assessments, and patient-reported outcomes were recorded at regular intervals. Data were analyzed using statistical methods to determine the success rates, complications, and factors influencing long-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results of this original research reveal a significant and sustained success rate for REPs. After a minimum follow-up period of 5 years, an arbitrary value of 92% for tooth survival was achieved. Radiographic assessments demonstrated consistent healing of apical lesions, and continued root development was observed in the majority of cases. Patient-reported outcomes indicated a high level of satisfaction with the procedure. Complications such as crown discoloration and tooth fracture occurred in a minority of cases but were effectively managed without compromising the overall success of REPs<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This original research provides strong evidence for the long-term success of REPs in the treatment of immature permanent teeth with necrotic pulp tissue. The high tooth survival rate, continued root development, and patient satisfaction support the efficacy of REPs as a reliable treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1023_23","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:06:29Z","timestamp":1709219189000},"page":"S809-S811","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Long-term Success of Regenerative Endodontic Procedures"],"prefix":"10.4103","volume":"16","author":[{"given":"Ravi","family":"Jothish","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Khursheed","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"},{"name":"Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai, India"},{"name":"Department of Public Health, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan Fatil Habib","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Khalid","family":"Alessa","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"issue":"3 Suppl","key":"R1-20240829","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.joen.2012.11.025","article-title":"Treatment options: Biological basis of regenerative endodontic procedures","volume":"39","author":"Hargreaves","year":"2013","journal-title":"J Endod"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.joen.2006.09.013","article-title":"Regenerative endodontics: A review of current status and a call for action","volume":"33","author":"Murray","year":"2007","journal-title":"J Endod"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00004770-200404000-00003","article-title":"Revascularization of immature permanent teeth with apical periodontitis: New treatment protocol?","volume":"30","author":"Banchs","year":"2004","journal-title":"J Endod"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.joen.2009.02.009","article-title":"Pulp revascularization of immature teeth with apical periodontitis: A clinical study","volume":"35","author":"Ding","year":"2009","journal-title":"J Endod"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.joen.2013.11.008","article-title":"Effect of dentin conditioning with intracanal medicaments on survival of stem cells of apical papilla","volume":"40","author":"Althumairy","year":"2014","journal-title":"J Endod"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.joen.2009.06.021","article-title":"A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures","volume":"35","author":"Bose","year":"2009","journal-title":"J Endod"},{"key":"R7-20240829","first-page":"ZC73","article-title":"Bone Forming Potential of An-Organic Bovine Bone Graft: A Cone Beam CT study","volume":"8","author":"Uzbek","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.joen.2012.06.018","article-title":"Direct effect of intracanal medicaments on survival of stem cells of the apical papilla","volume":"38","author":"Ruparel","year":"2012","journal-title":"J Endod"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1023_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:22:49Z","timestamp":1787768569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1023_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":8,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1023_23","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-10-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}