{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:17Z","timestamp":1787840777628,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n \n This study emphasizes the efficacy of triphala as a therapeutic agent over inflammatory condition in hydrogen sulfide (H\n 2<\/jats:sub>\n S) mediated inflammatory path in the presence of titanium (Ti) discs.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and method:<\/jats:title>\n In the presence of triphala extracts, lipopolysaccharidetreated macrophages showed reduction in production of inflammatory mediators and intercellular free radicals (ROS) and downregulation of mRNA in TNF.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Thus in the presence of propargylglycine, reduction of TNF\u03b1 by triphala in the H\n 2<\/jats:sub>\n S inhibited group showed that the mechanism of action of triphala can be through the H\n 2<\/jats:sub>\n S pathway\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1058_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:04:00Z","timestamp":1738235040000},"page":"S4514-S4516","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["TNF-\u03b1, An Inflammatory Path, Rerouted Through Alternate Medicinal Channels"],"prefix":"10.4103","volume":"16","author":[{"given":"Shyam Sundar","family":"Shanker","sequence":"first","affiliation":[{"name":"Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Hussain","sequence":"additional","affiliation":[{"name":"Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annapoorni","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamizhselvi","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jep.2013.08.025","article-title":"Evaluating the anti-inflammatory potential of Tectaria cicutaria L. rhizome extract in vitro as well as in vivo","volume":"150","author":"Choudhari","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"R2-20250130","first-page":"71","article-title":"Triphala \u2013the sanctifying medicine to human domain:A review","volume":"10","author":"Revathi","year":"2018","journal-title":"Der Pharmacia Lettre,"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF:A road to inflammation","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/1547691X.2015.1136010","article-title":"Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-\u03baB pathway","volume":"13","author":"Kalaiselvan","year":"2016","journal-title":"J immunotoxicol"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/ars.2009.2899","article-title":"The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages","volume":"12","author":"Whiteman","year":"2010","journal-title":"Antioxid Redox Signal"}],"container-title":["Journal of 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History"}},{"value":"2024-09-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}