{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:34Z","timestamp":1787840794197,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n MacrophagesHydrogen sulfide (H2 S), an endogenously produced gasotransmitter, is a wellknown inflammatory agent production successfully controlled with triphala in macrophages.<\/jats:p>\n <\/jats:sec>\n \n Materials and method:<\/jats:title>\n The ELISA analysis revealed that triphala extracts suppress the protein expression of NF\u03baB (p65) and downregulation of the CSE gene expression. Moreover, in the presence of propargylglycine (PAG) the expression of NF\u03baB and CSE gene was further reduced.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n These results suggest that triphala could be a potent antiinflammatory effect that could be used for the treatment of many inflammatory disorders, including periimplantitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1059_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:05:09Z","timestamp":1738235109000},"page":"S4511-S4513","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Protective Effect of Triphala Mediated by H2S Signaling Pathway in LPS-Induced RAW Macrophages"],"prefix":"10.4103","volume":"16","author":[{"given":"Shyam Sundar","family":"Shanker","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Crown and Bridge, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiasha","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Biosciences, School of Bioscience and Technology, Vellore Institute of Technology, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Crown And Bridge, Madha Dental College and Hospital, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Annapoorni","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Crown and Bridge, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy","family":"Tamizhselvi","sequence":"additional","affiliation":[{"name":"Department of Biosciences, School of Bioscience and Technology, Vellore Institute of Technology, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jep.2013.08.025","article-title":"Evaluating the anti-inflammatory potential of Tectaria cicutaria L. rhizome extract in vitro as well as in vivo","volume":"150","author":"Choudhari","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"105119","DOI":"10.1016\/j.phrs.2020.105119","article-title":"Hydrogen sulfide:An endogenous regulator of the immune system","volume":"161","author":"Dilek","year":"2020","journal-title":"Pharmacol Res"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"e17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/ars.2009.2899","article-title":"The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages","volume":"12","author":"Whiteman","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1007\/s11033-019-04725-7","article-title":"Expression and activity of hydrogen sulfide generating enzymes in murine macrophages stimulated with lipopolysaccharide and interferon-\u03b3","volume":"46","author":"BronowickaAdamska","year":"2019","journal-title":"Mol Biol Rep"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1059_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:11Z","timestamp":1787837351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1059_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":5,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1059_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}