{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:47Z","timestamp":1787071487503,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early childhood caries is a significant public health issue in India, particularly in underserved rural and tribal communities. Silver diamine fluoride (SDF) has emerged as a noninvasive, low-cost treatment to arrest dental caries in young children. This study evaluates the effectiveness of 38% SDF compared to high-fluoride-releasing glass ionomer cement (GIC) in arresting active dentinal caries among preschool children attending Anganwadi Kendras in the Angara Block, Ranchi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A parallel-group, stratified cluster randomized controlled trial will be conducted over 24 months. A total of 400 children aged 3\u20136 years with the International Caries Detection and Assessment System (ICDAS) score of 5 or 6 active caries lesions will be recruited from 60 Anganwadi centres across six sectors in Angara Block, Ranchi. Children will be randomized at the Anganwadi cluster level into two groups: Group A (intervention) will receive 38% SDF and Group B (control) will receive high fluoride GIC restorations. Caries arrest will be evaluated using ICDAS criteria and visual-tactile assessment at 6, 12, 18, and 24 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Expected Outcomes:<\/jats:title>\n                    <jats:p>The study anticipates that SDF will demonstrate comparable or superior efficacy in arresting caries relative to GIC in a community setting. Findings will support the use of SDF as a cost-effective, minimally invasive strategy suitable for integration into national oral health programs targeting young children in resource-constrained environments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1077_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:02:00Z","timestamp":1766044920000},"page":"S3420-S3422","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Protocol for Effectiveness of Silver Diamine Fluoride in Arresting Caries in 3\u20136-year-old Children: A Community-Based Randomized Control Trial"],"prefix":"10.4103","volume":"17","author":[{"given":"Swati","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pedodontic and Preventive Dentistry, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy Kumar","family":"Shahi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Saigal","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Microbiology and Forensic Odontology, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Arunesh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sinha","sequence":"additional","affiliation":[{"name":"Model Rural Health Research Unit, Angara, & ICMR - National Institute of Malaria Research, Field Unit, Ranchi Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Model Rural Health Research Unit, Angara, & ICMR - National Institute of Malaria Research, Field Unit, Ranchi Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.acap.2009.08.006","article-title":"Update on early childhood caries since the surgeon general\u2019s report","volume":"9","author":"Tinanoff","year":"2009","journal-title":"Acad Pediatr"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global burden of untreated caries: A systematic review and metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J Dent Res"},{"key":"R3-20251218","first-page":"480","article-title":"A review of repeat general anesthesia for pediatric dental surgery in Alberta, Canada","volume":"29","author":"Schroth","year":"2007","journal-title":"Pediatr Dent"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"313","DOI":"10.17245\/jdapm.2019.19.6.313","article-title":"General anesthesia in the management of early childhood caries: An overview","volume":"19","author":"Oubenyahya","year":"2019","journal-title":"J Dent Anesth Pain Med"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/0022034518774783","article-title":"Arresting dentine caries with silver diamine fluoride: What\u2019s behind it?","volume":"97","author":"Mei","year":"2018","journal-title":"J Dent Res"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12903-016-0171-6","article-title":"Caries remineralisation and arresting effect in children by professionally applied fluoride treatment-A systematic review","volume":"16","author":"Gao","year":"2016","journal-title":"BMC Oral Health"},{"key":"R7-20251218","first-page":"135","article-title":"Use of silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs","volume":"39","author":"Crystal","year":"2017","journal-title":"Pediatr Dent"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12903-015-0033-7","article-title":"Non-surgical treatment of dentin caries in preschool children--systematic review","volume":"15","author":"Duangthip","year":"2015","journal-title":"BMC Oral Health"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000488686","article-title":"The Effect of Silver Diamine Fluoride in Preventing Caries in the Primary Dentition: A Systematic Review and Meta-Analysis","volume":"53","author":"Oliveira","year":"2019","journal-title":"Caries Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1077_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:50Z","timestamp":1787068010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1077_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1077_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-06-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}