{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:44Z","timestamp":1787771984263,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Although immunization against coronavirus disease 2019 (COVID-19) is ongoing, adverse reactions to these vaccinations have been observed in isolated cases. We aimed to report different neurological complications developed after COVID-19 vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In our case series study, we report all cases of CNS demyelination following COVID-19 immunization. Clinical evaluation, brain MRI, and CSF analysis for oligoclonal bands and IgG index were performed for all patients. Other investigations were performed for selected patients, including spine MRI, EEG, VEP, and aquaporin-4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eighteen patients (eight males and ten females) with no history of COVID-19 infection had neurological manifestations (vertigo, ataxia, recurrent attacks of loss of consciousness, optic neuritis, and myelitis) starting within 14 days after Pfizer (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12) and AstraZeneca (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6) vaccination. MRI was obtained during the acute stage of the disease. The most common presenting symptoms were optic neuritis and hemiparesis. Sixteen patients had altered signal intensity and multiple variable-sized, round to ill-defined oval lesions suggestive of MS. Two showed findings compatible with transverse myelitis\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study identified CNS demyelination complications after COVID-19 vaccination. The COVID-19 vaccination could result in CNS complications, possibly connected to a post-vaccination inflammatory process. We recommend continuous post-marketing monitoring for adverse reactions in individuals who received the vaccines to establish a connection and guarantee the long-term safety of COVID-19 vaccines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1084_23","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:11:50Z","timestamp":1709219510000},"page":"S1002-S1006","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["CNS Demyelination Syndromes Following COVID-19 Vaccination: A Case Series"],"prefix":"10.4103","volume":"16","author":[{"given":"Yasser","family":"Hamed","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd-Elaziz","family":"Shokry","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled Mohamed Ali","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma Mokhtar","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safwat Salama","family":"Sawy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Abdelrazzak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omran Mohamed","family":"Abdelmola","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Faculty of Medicine, Al-Azhar University- Assiut Branch, 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