{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:45Z","timestamp":1787840805678,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Stevens-Johnson syndrome (SJS) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome are rare conditions, representing severe hypersensitivity reactions with significant oral presentations. SJS is an uncommon but severe variant of erythema multiforme, presenting skin and mucosal eruptions that can be potentially fatal. DRESS syndrome, similarly, involves a severe hypersensitivity reaction characterized by fever, rash, and organ involvement. DRESS syndrome is a rare but severe drug-induced hypersensitivity reaction characterized by fever, rash, eosinophilia, and internal organ involvement. The condition often presents with elevated liver enzymes and systemic symptoms that necessitate prompt diagnosis and treatment. This report discusses a case of DRESS syndrome in a 41-year-old patient, highlighting the clinical presentation, investigations, differential diagnosis, and treatment approach. Both conditions require prompt diagnosis and treatment, often involving hospitalization. This report discusses two cases of severe hypersensitivity reactions with oral manifestations.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1090_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:06:44Z","timestamp":1738235204000},"page":"S4935-S4939","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Severe Hypersensitivity Reactions with Oral Manifestations: Case Reports on Stevens-Johnson Syndrome and DRESS Syndrome"],"prefix":"10.4103","volume":"16","author":[{"given":"Sura A. A. Fuoad","family":"Al-Bayati","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Surgical Dental Sciences, College of Dentistry\/Gulf Medical University, Ajman, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3390\/ijms22042147","article-title":"Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome\/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS\/DRESS)","volume":"22","author":"Miyagawa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3390\/biomedicines10092105","article-title":"A review of the systemic treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"10","author":"Wang","year":"2022","journal-title":"Biomedicines"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"1213889","DOI":"10.3389\/fmed.2023.1213889","article-title":"Updates in SJS\/TEN:collaboration, innovation, and community","volume":"10","author":"Marks","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"R4-20250130","first-page":"1234","article-title":"Overview of severe cutaneous adverse reactions (SCARs):Pathophysiology, diagnosis, and management","volume":"402","author":"Harr","year":"2024","journal-title":"Lancet"},{"key":"R5-20250130","article-title":"Advances in understanding of the pathogenesis and therapeutic implications of drug reaction with eosinophilia and systemic symptoms:An updated review","volume":"10","author":"Wu","year":"2023","journal-title":"Front Immunol"},{"key":"R6-20250130","first-page":"2251","article-title":"DRESS and Stevens-Johnson Syndrome Overlap Secondary to Allopurinol in a 50-Year-Old Man-A Diagnostic and Treatment Challenge:Case Report","volume":"13","author":"Mart\u00ednez","year":"2023","journal-title":"Life (Basel)"},{"key":"R7-20250130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13671-021-00348-z","article-title":"Updates and Insights in the Diagnosis and Management of DRESS Syndrome","volume":"10","author":"Schunkert","year":"2021","journal-title":"Curr Dermatol Rep"},{"key":"R8-20250130","first-page":"10","article-title":"Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood:A narrative review","author":"Manieri","year":"2023","journal-title":"Front Pediatr"},{"key":"R9-20250130","first-page":"3403","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis:Clinical patterns, diagnostic considerations, and therapeutic management","volume":"10","author":"Mockenhaupt","year":"2021","journal-title":"J Clin Med"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1090_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:25Z","timestamp":1787837365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1090_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1090_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}