{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:39Z","timestamp":1787840799078,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Aim:<\/jats:title>\n \n To evaluate the antifungal activity of Triple Antibiotic Paste (TAP) with Epigallocatechin Gallate (EGCG) against\n Candida albicans<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Disk diffusion test: Thirty Kirby\u2013Bauer disks were soaked in: Group 1\u2014TAP (ciprofloxacin, minocycline, and metronidazole in saline); Group 2\u2014TAP + EGCG + saline; Group 3\u2014EGCG + saline; Group 4\u2014Fluconazole. Disks were dried, placed in a\n C.albicans<\/jats:italic>\n suspension, and incubated at 37\u00b0C for 24 hours. Zones of inhibition were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Simulated Dentine Study:<\/jats:title>\n \n Forty single-rooted teeth were decoronated to 12 mm, cleaned and shaped with ProTaper files, and irrigated with saline. Canals were inoculated with\n C.albicans<\/jats:italic>\n , treated with medicaments after two days, and incubated for three days. After saline irrigation, sterile absorbent points were placed in Sabouraud Dextrose Agar for 48-hour incubation at 37\u00b0C. Colony-forming units (CFUs) were counted.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Fluconazole produced the largest zones of inhibition, significantly larger than EGCG, EGCG + Fluconazole, and TAP + EGCG (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n C.albicans<\/jats:italic>\n is susceptible to EGCG, with Fluconazole exhibiting the greatest antifungal activity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1093_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:05:01Z","timestamp":1738235101000},"page":"S4855-S4857","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Candidal Action of Epigallocatechin Gallate as Intracanal Medicament\u2014A Microbiological and Dentin Model Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Shekar","family":"Shobana","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Tagore Dental College and Hospital, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandavelu","family":"Sujareetha","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Tagore Dental College and Hospital, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokkalingam M.","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Tagore Dental College and Hospital, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagarajan","family":"Geethapriya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sree Balaji Dental College and Hospital BIHER University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Sarath","family":"Sarathy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Thai Moogambigai Dental College and Hospital, Dr. M. G. R. Educational and Research Institute, Deemed University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghunathan","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Tagore Dental College and Hospital, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.joen.2011.06.032","article-title":"Analysis of the cause of failure in nonsurgical endodontic treatment by microscopic inspection during endodontic microsurgery","volume":"37","author":"Song","year":"2011","journal-title":"J Endod"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.joen.2008.05.008","article-title":"Microorganisms in root canal\u2013treated teeth from a German population","volume":"34","author":"Rocas","year":"2008","journal-title":"J Endod"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1600-0722.2004.00144.x","article-title":"In vitro antibacterial effect of calcium hydroxide combined with chlorhexidine or iodine potassium iodide on enterococcus faecalis","volume":"112","author":"Sir\u00e9n","year":"2004","journal-title":"Eur J Oral Sci"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.1365-2591.1999.00195.x","article-title":"Susceptibility of oral candida species to calcium hydroxide in vitro","volume":"32","author":"Waltimo","year":"1999","journal-title":"Int Endod J"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.5005\/jp-journals-10024-2939","article-title":"Comparative study of antifungal efficacy of various endodontic irrigants with and without clotrimazole in extracted teeth inoculated with candida albicans","volume":"21","author":"Srinivasan","year":"2020","journal-title":"J Contemp Dent Pract"},{"issue":"(Suppl 1)","key":"R7-20250130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0732-8893(89)90141-7","article-title":"Review of fluconazole:A new triazole antifungal agent","volume":"12","author":"Washton","year":"1989","journal-title":"Diagn Microbiol Infect Dis"},{"key":"R8-20250130","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.phytochem.2006.06.020","article-title":"Epigallocatechin-3-gallate (EGCG):Chemical and biomedical perspectives","volume":"67","author":"Nagle","year":"2006","journal-title":"Phytochemistry"},{"key":"R9-20250130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/jac\/dkh046","article-title":"Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans","volume":"53","author":"Hirasawa","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"R10-20250130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/0976-237X.62519","article-title":"Nonsurgical healing of large periradicular lesions using a triple antibiotic paste:A case series","volume":"1","author":"Taneja","year":"2010","journal-title":"Contemp Clin Dent"},{"key":"R11-20250130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5005\/jp-journals-10024-2494","article-title":"Assessment of antimicrobial activity of different intracanal medicaments against enterococcus faecalis and candida albicans:An in vitro study","volume":"20","author":"Jayakkodi","year":"2019","journal-title":"J Contemp Dent Pract"},{"key":"R12-20250130","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1222236","article-title":"Tackling human fungal infections","volume":"336","author":"Brown","year":"2012","journal-title":"Science"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1093_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:13Z","timestamp":1787837353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1093_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":11,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1093_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}