{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:23:19Z","timestamp":1787772199792,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Carious exposure of an irreversibly inflamed vital pulp in a young permanent tooth presents a significant clinical challenge to clinicians to maintain the vitality. Direct pulp capping, partial pulpotomy, and complete pulpotomy are the available procedures to treat young permanent tooth. Mineral trioxide aggregate and biodentine are currently the material of choice for these procedures. The present case report describes the successful apexogenesis of mandibular left first permanent molar using mineral trioxide aggregate. The 18-month follow-up of the case demonstrated clinical and radiographic success with absence of any signs and symptoms and continued root formation.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1109_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:32:15Z","timestamp":1713270735000},"page":"S1863-S1866","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Apexogenesis of an Immature Permanent Molar with Irreversible Pulpitis Using Mineral Trioxide Aggregate Pulpotomy: A Case Report"],"prefix":"10.4103","volume":"16","author":[{"given":"Mohamed Rahoof","family":"ArakkalVettath","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal S.","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Alyeezadi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthhin","family":"Almuthhin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman I","family":".Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola H. Gadoe","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tabuk Specialist Dental Centre, Ministry of Health in Tabuk City, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"4","DOI":"10.15562\/jdmfs.v2i1.462","article-title":"Management pain and anxiety in endodontic treatment","volume":"2","author":"Sumidarti","year":"2017","journal-title":"J Dentomaxillofac Sci"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00784-014-1244-z","article-title":"Five-year results of vital pulp therapy in permanent molars with irreversible pulpitis:A non-inferiority multicenter randomized clinical trial","volume":"19","author":"Asgary","year":"2015","journal-title":"Clin Oral Investig"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.joen.2009.11.025","article-title":"Apexogenesis treatment with a new endodontic cement:A case report","volume":"36","author":"Nosrat","year":"2010","journal-title":"J Endod"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/00004770-200310000-00008","article-title":"Identification of hard tissue after experimental pulp capping using dentin sialoprotein (DSP) as a marker","volume":"29","author":"Andelin","year":"2003","journal-title":"J Endod"},{"key":"R5-20240829","first-page":"85","article-title":"Clinical and histological evaluation of white ProRoot MTA in direct pulp capping","volume":"19","author":"Iwamoto","year":"2006","journal-title":"Am J Dent"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0030-4220(73)90101-1","article-title":"Dental pulp pathosis. Clinicopathologic correlations based on 109 cases","volume":"35","author":"Garfunkel","year":"1973","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.joen.2014.08.010","article-title":"Correlation between clinical and histologic pulp diagnoses","volume":"40","author":"Ricucci","year":"2014","journal-title":"J Endod"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.joen.2017.06.013","article-title":"Mandibular premolars with immature roots and apical periodontitis lesions treated with pulpotomy:Report of 3 cases","volume":"43","author":"Tsukiboshi","year":"2017","journal-title":"J Endod"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"103158","DOI":"10.1016\/j.jdent.2019.06.005","article-title":"Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis:A systematic review","volume":"88","author":"Cushley","year":"2019","journal-title":"J Dent"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0099-2399(96)80017-3","article-title":"A clinical study of direct pulp capping applied to carious-exposed pulps","volume":"22","author":"Matsuo","year":"1996","journal-title":"J Endod"},{"issue":"7 Suppl","key":"R11-20240829","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.joen.2008.02.030","article-title":"Vital pulp therapy with new materials:New directions and treatment perspectives--permanent teeth","volume":"34","author":"Witherspoon","year":"2008","journal-title":"J Endod"},{"key":"R12-20240829","first-page":"182","article-title":"Clinical and radiographic evaluation of adhesive pulp capping in primary molars following hemostasis with 1.25% sodium hypochlorite:2-year results","volume":"20","author":"Demir","year":"2007","journal-title":"Am J Dent"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.joen.2009.09.009","article-title":"Mineral trioxide aggregate:A comprehensive literature review--Part III:Clinical applications, drawbacks, and mechanism of action","volume":"36","author":"Parirokh","year":"2010","journal-title":"J Endod"},{"key":"R14-20240829","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1747-4477.2009.00166.x","article-title":"MTA pulpotomy of human permanent molars with irreversible pulpitis","volume":"35","author":"Eghbal","year":"2009","journal-title":"Aust Endod J"},{"key":"R15-20240829","first-page":"393","article-title":"Comparing gray mineral trioxide aggregate and diluted formocresol in pulpotomized human primary molars","volume":"32","author":"Zealand","year":"2010","journal-title":"Pediatr Dent"},{"key":"R16-20240829","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.jdent.2014.06.007","article-title":"MTA pulpotomy as an alternative to root canal treatment in children's permanent teeth in a dental public health setting","volume":"42","author":"Alqaderi","year":"2014","journal-title":"J Dent"},{"key":"R17-20240829","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.joen.2016.10.027","article-title":"Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure:The retrospective study","volume":"43","author":"Linsuwanont","year":"2017","journal-title":"J Endod"},{"key":"R18-20240829","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jdent.2007.04.008","article-title":"Dissolution of bio-active dentine matrix components by mineral trioxide aggregate","volume":"35","author":"Tomson","year":"2007","journal-title":"J Dent"},{"key":"R19-20240829","doi-asserted-by":"crossref","first-page":"8788358","DOI":"10.1155\/2022\/8788358","article-title":"The understanding of vital pulp therapy in permanent teeth:A new perspective","volume":"2022","author":"Shang","year":"2022","journal-title":"Biomed Res Int"},{"key":"R20-20240829","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jdent.2015.06.010","article-title":"Permanent teeth pulpotomy survival analysis:Retrospective follow-up","volume":"43","author":"Kunert","year":"2015","journal-title":"J Dent"},{"key":"R21-20240829","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2591.2006.01180.x","article-title":"Quality guidelines for endodontic treatment:Consensus report of the European Society of Endodontology","volume":"39","author":"European","year":"2006","journal-title":"Int Endod J"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1109_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:33:07Z","timestamp":1787769187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1109_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":21,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1109_23","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-10-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}