{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:22:50Z","timestamp":1791177770519,"version":"4.1.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n T2DM is known to cause chronic hyperglycemia and results in a set of systemic complications. Hematological parameters, red cell indices testing, and platelet parameters in combination with white cell count may also become the parameters of inflammatory status and glycemic control.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Patients diagnosed with T2DM were enrolled in a cross-sectional observational study with 120 subjects (90 diagnosed with T2DM and 30 age- and sex-matched controls). An automated hematology analyser was used to carry out complete blood counts (CBC). The measurements that were conducted on HbA1c used HPLC. The T2DM patients were divided into three groups based on glycemic control; there were good glycemic control (HbA1c 7.0% or less), moderate (HbA1c 7.1-8.5%), and poor control (HbA1c 8.5% or more).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The T2DM patients had a considerable increment in total leukocyte count (mean = 8.94 10 9\/L) and neutrophil-to-lymphocyte ratio (NLR = 2.97) as compared with the controls (mean WBC = 6.21 10 9\/L, NLR = 1.85). The mean platelet volume (MPV) value was higher in poorly-controlled diabetics (11.2 fL) than in the well-controlled ones (9.4 fL). There was a negative relationship between HbA1c and hemoglobin levels (\n r<\/jats:italic>\n = \u20130.45,\n P<\/jats:italic>\n = 0.01), whereas positive relationships with HbA1c and WBC count (\n r<\/jats:italic>\n = 0.38,\n P<\/jats:italic>\n = 0.02) and MPV (\n r<\/jats:italic>\n = 0.42,\n P<\/jats:italic>\n = 0.01), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n T2DM is linked with immense changes in blood and lab values, especially among those with mixed glycemic control. Higher WBC, MPV, and NLR indicate a low level of inflammation and hyperactivity of platelets, which might also be a risk factor that leads to complications of diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1111_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:02:29Z","timestamp":1766044949000},"page":"S3102-S3104","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Hematological Changes in Type 2 Diabetes Mellitus and Their Correlation with Glycemic Control"],"prefix":"10.4103","volume":"17","author":[{"given":"Amisha","family":"Khungala","sequence":"first","affiliation":[{"name":"Department of Medicine, GMERS General Hospital, Junagadh, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vacha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Dr. N. D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrudali","family":"Babaria","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, GMERS Medical College and Hospital, Vadnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul Bhaveshbhai","family":"Vaghasiya","sequence":"additional","affiliation":[{"name":"Department of Medicine, GMERS General Hospital, Junagadh, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2478\/jomb-2018-0021","article-title":"Relationship between hematological parameters and glycemic control in type 2 diabetes mellitus patients","volume":"38","author":"Milosevic","year":"2019","journal-title":"J Med Biochem"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"e0272145","DOI":"10.1371\/journal.pone.0272145","article-title":"Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study","volume":"17","author":"Ebrahim","year":"2022","journal-title":"PLoS One"},{"key":"R3-20251218","first-page":"431","article-title":"[Relationship between brachial-ankle pulse wave velocity and glycemic control of type 2 diabetes mellitus patients in Beijing community population]","volume":"47","author":"Sun","year":"2015","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"R4-20251218","first-page":"11420","article-title":"Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes","volume":"8","author":"Demirtas","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5455\/medarh.2019.73.163-168","article-title":"The triglyceride\/HDL ratio and triglyceride glucose index as predictors of glycemic control in patients with diabetes mellitus type 2","volume":"73","author":"Babic","year":"2019","journal-title":"Med Arch"},{"key":"R6-20251218","first-page":"26","article-title":"Study of impact of glycemic status (HbA1c) on platelet activity measured by mean platelet volume & vascular complications in diabetics","volume":"67","author":"Saluja","year":"2019","journal-title":"J Assoc Physicians India"},{"key":"R7-20251218","first-page":"65","article-title":"Positive relationship of platelet volume indices with HbA1c in unselected type-2 diabetes mellitus patients","author":"Wu","year":"2019","journal-title":"Clin Lab"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1111_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:56Z","timestamp":1787068016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1111_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":7,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1111_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-06-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}