{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:03Z","timestamp":1787772123409,"version":"build-2784847793"},"reference-count":92,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Inflammatory chemicals are released by the immune system in response to any perceived danger, including irritants and pathogenic organisms. The caspase activation and the response of inflammation are governed by inflammasomes, which are sensors and transmitters of the innate immune system. They have always been linked to swelling and pain. Research has mainly concentrated on the NOD-like protein transmitter 3 (NLRP3) inflammasome. Interleukin (IL)-1 and IL-18 are pro-inflammatory cytokines that are activated by the NOD-like antibody protein receptor 3 (NLRP3), which controls innate immune responses. The NLRP3 inflammasome has been associated with gum disease and other autoimmune inflammatory diseases in several studies. Scientists\u2019 discovery of IL-1\u2019s central role in the pathophysiology of numerous autoimmune disorders has increased public awareness of these conditions. The first disease to be connected with aberrant inflammasome activation was the autoinflammatory cryopyrin-associated periodic syndrome (CAPS). Targeted therapeutics against IL-1 have been delayed in development because their underlying reasons are poorly understood. The NLRP3 inflammasome has recently been related to higher production and activation in periodontitis. Multiple periodontal cell types are controlled by the NLRP3 inflammasome. To promote osteoclast genesis, the NLRP3 inflammasome either increases receptor-activator of nuclear factor kappa beta ligand (RANKL) synthesis or decreases osteoclast-promoting gene (OPG) levels. By boosting cytokines that promote inflammation in the periodontal ligament fibroblasts and triggering apoptosis in osteoblasts, the NLRP3 inflammasome regulates immune cell activity. These findings support further investigation into the NLRP3 inflammasome as a therapeutic target for the medical treatment of periodontitis. This article provides a short overview of the NLRP3 inflammatory proteins and discusses their role in the onset of autoinflammatory disorders (AIDs) and periodontitis.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1118_23","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T18:22:56Z","timestamp":1711563776000},"page":"S1110-S1119","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["NLRP3 Inflammasome in Autoinflammatory Diseases and Periodontitis Advance in the Management"],"prefix":"10.4103","volume":"16","author":[{"given":"Nada","family":"Hashim","sequence":"first","affiliation":[{"name":"RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras al-Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Babiker","sequence":"additional","affiliation":[{"name":"RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras-al-Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Mohammed","sequence":"additional","affiliation":[{"name":"RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras al-Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mustahsen","family":"Rehman","sequence":"additional","affiliation":[{"name":"RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras al-Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallan CSK","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras al-Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakri","family":"Gobara","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of Khartoum, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: Guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3810\/pgm.2010.09.2209","article-title":"Inflammasome-mediated autoinflammatory disorders","volume":"122","author":"Wilson","year":"2010","journal-title":"Postgrad 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