{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:21Z","timestamp":1787840781208,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Periodontal disease, a chronic inflammatory condition, has been increasingly associated with systemic health issues, particularly cardiovascular diseases. This systematic review and meta-analysis explores the role of genetic mutations in periodontitis patients with cardiovascular diseases and allied ailments.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n Conducted a comprehensive search across databases including PubMed, EMBASE, and Cochrane Library to identify relevant studies on the association between genetic mutations, periodontal disease severity, and cardiovascular outcomes. Sixteen studies met the inclusion criteria, primarily comprising observational studies with varying levels of risk of bias.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Our analysis revealed that specific genetic mutations, such as those in TLR 2, TLR 4, NF-kB, and IL-4 genes, significantly increase the risk of periodontitis and exacerbate cardiovascular conditions like coronary artery disease, myocardial infarction, and stroke. These findings underscore the importance of integrating genetic screening into the management of periodontal and cardiovascular diseases. The results also emphasize the need for interdisciplinary collaboration between dental and medical professionals to develop personalized treatment strategies.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In conclusion, genetic mutations play a pivotal role in the susceptibility and severity of periodontitis in patients with cardiovascular diseases. Understanding these genetic factors could lead to improved diagnostic tools and therapeutic approaches, addressing the dual burden of periodontal disease and cardiovascular ailments. Future research should focus on large-scale, longitudinal studies to further elucidate the molecular mechanisms and develop targeted interventions for these interconnected health issues.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1129_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:03:57Z","timestamp":1738235037000},"page":"S4327-S4330","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of Genetic Mutations in Periodontitis Patients with Cardiovascular Diseases and Allied Ailments: A Systematic Review and Meta-analysis"],"prefix":"10.4103","volume":"16","author":[{"given":"Pragathi","family":"Yatham","sequence":"first","affiliation":[{"name":"Department of Microbiology, Meenakshi Institute of Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Jaideep","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ramadevi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Government Medical College, Mahabubnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha L.","family":"Pogula","sequence":"additional","affiliation":[{"name":"Department of Physiology, Meenakshi Institute of Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research (MAHER), Kanchipuram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panneerselvam","family":"Periasamy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Government Erode Medical College, Perundurai, Affiliated Under The Tamil Nadu Dr MGR Medical University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"766944","DOI":"10.3389\/fcimb.2021.766944","article-title":"Periodontal disease:The good, the bad, and the unknown","volume":"11","author":"Sedghi","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"R2-20250130","first-page":"7","article-title":"Clinical and public health implications of periodontal and systemic diseases:An overview Periodontol 2000","volume":"83","author":"Genco","year":"2020"},{"key":"R3-20250130","article-title":"Present and future non-surgical therapeutic strategies for the management of periodontal diseases","author":"Renata","year":"2012","journal-title":"Periodontal Diseases - A Clinician's Guide. Macmillan"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/jech-2015-206745","article-title":"Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in The Netherlands","volume":"71","author":"Beukers","year":"2017","journal-title":"J Epidemiol Community Health"},{"issue":"Suppl 1","key":"R5-20250130","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.4103\/jpbs.jpbs_517_22","article-title":"Periodontal diseases and heart diseases:A systemic review","volume":"15","author":"Alwithanani","year":"2023","journal-title":"J Pharmacy Bioallied Sci"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"9720947","DOI":"10.1155\/2023\/9720947","article-title":"Periodontal Health and Disease in the Context of Systemic Diseases","volume":"2023","author":"Isola","year":"2023","journal-title":"Mediators Inflamm"},{"key":"R7-20250130","first-page":"780649","article-title":"Targeting epigenetics and non-coding RNAs in myocardial infarction:From mechanisms to therapeutics","volume":"12","author":"Chen","year":"2021","journal-title":"Frontiers Media"},{"key":"R8-20250130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0757.2011.00397.x","article-title":"Principles of periodontology","volume":"61","author":"Dentino","year":"2012","journal-title":"Periodontol 2000"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1129_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:28:52Z","timestamp":1787837332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1129_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":8,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1129_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}