{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:28:41Z","timestamp":1787840921080,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Chronic inflammation of the tooth\u2019s supporting tissues is known as periodontal disease. It causes pockets to develop, attachments to break, and eventually the loss of teeth. Because of their well-known anti-inflammatory qualities, omega-3 fatty acids have been recommended as an additional therapy for periodontal inflammation.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A randomized controlled study of 60 individuals suffering from persistent periodontitis was carried out. Two groups of participants were randomly assigned: The test group (n = 30) got conventional periodontal treatment with omega-3 fatty acid supplementation (1000 mg\/day), while the control group (n = 30) received normal periodontal therapy alone. Measurements of periodontal parameters were made at baseline, 3 months, and 6 months after therapy, including bleeding on probing (BOP) and pocket depth. Paired t-tests and analysis of variance were used in the statistical analysis to determine the significance of the group differences.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Participants in the test group showed a greater reduction in probing pocket depth (PPD) and BOP at both 3 and 6 months. Specifically, the mean PPD decreased from 5.4 \u00b1 0.7 mm to 3.0 \u00b1 0.4 mm, and BOP reduced from 71.2 \u00b1 14.5% to 28.3 \u00b1 9.2% in the test group, with both outcomes showing statistically significant differences compared to the control group (\n P<\/jats:italic>\n < 0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In individuals with chronic periodontitis, omega-3 fatty acid supplementation dramatically improves the decrease of periodontal pocket depth and inflammation when administered as an adjuvant to regular periodontal treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1173_24","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T02:07:37Z","timestamp":1732068457000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction"],"prefix":"10.4103","author":[{"given":"E M Arshad","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implant Dentistry, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Dodani","sequence":"additional","affiliation":[{"name":"Department of Periodontology, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur Singh","family":"Rajpoot","sequence":"additional","affiliation":[{"name":"Department of Periodontology, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Choubey","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanchal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, M.M. Institute of Dental Sciences and Research, MM (Deemed to be University) Mullana Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"issue":"Suppl 11","key":"R1-20250114","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-051X.2010.01671.x","article-title":"How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?","volume":"38","author":"Preshaw","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"Suppl 14","key":"R2-20250114","first-page":"S106","article-title":"Working Group 2 of the Joint EFP\/AAP Workshop. Diabetes and periodontal diseases: Consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"40","author":"Chapple","year":"2013","journal-title":"J Clin Periodontol"},{"key":"R3-20250114","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"R4-20250114","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"R5-20250114","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0022034510385236","article-title":"Inflammation and uncoupling as mechanisms of periodontal bone loss","volume":"90","author":"Graves","year":"2011","journal-title":"J Dent Res"},{"key":"R6-20250114","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/0022034514541125","article-title":"Docosahexaenoic acid and periodontitis in adults: A randomized controlled trial","volume":"93","author":"Naqvi","year":"2014","journal-title":"J Dent Res"},{"key":"R7-20250114","first-page":"471","article-title":"Effect of Omega-3 fatty acids on chronic periodontitis patients. A randomized controlled trial","volume":"56","author":"Elkhouli","year":"2021","journal-title":"J Periodontal Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1173_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:47Z","timestamp":1787837447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1173_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":7,"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1173_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"2024-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}