{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:27:40Z","timestamp":1787840860826,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n \n The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic\n Saccharomyces boulardii<\/jats:italic>\n (\n S. boulardii<\/jats:italic>\n ) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) \u22655 mm and clinical attachment level (CAL) \u22653 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic\u2019s (\n S. boulardii<\/jats:italic>\n ) vitality was assessed both\n in vitro<\/jats:italic>\n and in the pocket.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group\u2019s PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group\u2019s BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in\n in vitro<\/jats:italic>\n vitality between the days, there was a significant difference and decrease in\n in vivo<\/jats:italic>\n viability in the days that followed as compared to the day before.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism\u2019s recolonization over time.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1175_24","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T02:01:46Z","timestamp":1732068106000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Split-Mouth Study to Evaluate the Adjunctive Role of Guided Pocket Recolonization (GPR) to Non-Surgical Periodontal Therapy"],"prefix":"10.4103","author":[{"given":"Yasir Shahab","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Medical and Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikram Singh","family":"Brahma","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Medical and Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Medical and Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Medical and Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Autonomous State Medical College, Hardoi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanu","family":"Sahney","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Medical and Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"R1-20250114","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/prd.12304","article-title":"Mechanisms underlying the association between periodontitis and atherosclerotic disease","volume":"83","author":"Schenkein","year":"2020","journal-title":"Periodontol 2000"},{"key":"R2-20250114","doi-asserted-by":"crossref","first-page":"587279","DOI":"10.1155\/2013\/587279","article-title":"Mixed red-complex bacterial infection in periodontitis","volume":"2013","author":"Suzuki","year":"2013","journal-title":"Int J Dent"},{"key":"R3-20250114","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5005\/jp-journals-10029-1145","article-title":"Efficacy of oral probiotics as an adjunct to scaling and root planing in nonsurgical treatment outcome of generalized chronic periodontitis patients: A clinico-microbiological study","volume":"6","author":"Mani","year":"2017","journal-title":"Int J Exp Dent Sci"},{"key":"R4-20250114","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/ijohs.ijohs_10_18","article-title":"Probiotics and periodontal disease","volume":"8","author":"Asok","year":"2018","journal-title":"Int J Oral Health Sci"},{"key":"R5-20250114","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4103\/0972-124X.154167","article-title":"The detection of BANA microorganisms in adult periodontitis before and after scaling and root planing by BANA-Enzymatic TM test kit: An in vivo study","volume":"19","author":"Dhalla","year":"2015","journal-title":"J Indian Soc Periodontol"},{"key":"R6-20250114","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1177\/154405910708601111","article-title":"Guiding periodontal pocket recolonization: A proof of concept","volume":"86","author":"Teughels","year":"2007","journal-title":"J Dent Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1175_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:47Z","timestamp":1787837447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1175_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":6,"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1175_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"2024-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}