{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:03Z","timestamp":1787840523498,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Injectable platelet-rich fibrin (i-PRF) is prepared without anticoagulants having improved features such as increased fibroblast migration, proliferation, and tissue angiogenesis acceleration. When administered to titanium implants, i-PRF clings to the metal surface, generating a protein coating that impacts cellular activity required for osseointegration which aids in optimum and rapid osseointegration. The present study compared and evaluated the osteogenic properties of i-PRF in dental implant sites to determine the positive impact of i-PRF on osseointegration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A split-mouth clinical study design was used, involving ten participants with twenty sites of bilaterally missing mandibular molars. The subjects were divided into two equal treatment groups (N = 10): control group, where dental implants were placed without i-PRF activation, and test group, where i-PRF-activated dental implants were placed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both groups showed similar trends in plaque index and sulcular bleeding index. However, the test group exhibited significantly higher Implant Stability Quotient scores, indicating better stability. Peri-implant probing depth showed no significant difference between groups, but the test group had lower increase in probing depth. In addition, the test group showed superior wound healing and lower crestal bone loss changes compared to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The findings of this study contributed to understand the effectiveness of i-PRF in enhancing osseointegration in dental implants, potentially improving clinical outcomes in implant dentistry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1179_24","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T02:02:32Z","timestamp":1732068152000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Clinical and Radiographic Changes Following Delayed Implant Placement in Mandibular Posterior Region with or without i-PRF Activation: A Split Mouth Clinical Study"],"prefix":"10.4103","author":[{"given":"Shivam","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir S.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajita","family":"Meenawat","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanu","family":"Sahney","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"R1-20250114","first-page":"220","article-title":"Evaluation of patient and implant characteristics as potential prognostic factors for oral implant failures","volume":"20","author":"Herrmann","year":"2005","journal-title":"Int J Oral Maxillofac Implants"},{"key":"R2-20250114","first-page":"53","article-title":"Efficacy of application of i- PRF to the surface of implants to improve osseointegration during the healing period: A split-mouth pilot study","volume":"14","author":"Fernandes","year":"2022","journal-title":"J Osseointegration"},{"key":"R3-20250114","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/0972-124X.94612","article-title":"Evaluation of immediately loaded dental implants bioactivated with platelet-rich plasma placed in the mandibular posterior region: A clinico-radiographic study","volume":"16","author":"Anand","year":"2012","journal-title":"J Indian Soc Periodontol"},{"key":"R4-20250114","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3889\/oamjms.2015.126","article-title":"Impact of platelet-rich plasma on bone height changes around platform switched implants supporting mandibular overdentures in controlled diabetic patients","volume":"3","author":"Ibraheem","year":"2015","journal-title":"Open Access Maced J Med Sci"},{"key":"R5-20250114","first-page":"112","article-title":"Osseointegration: Biological events in relation to characteristics of the implant surface: Clinical review","volume":"69","author":"Feller","year":"2014","journal-title":"S Afr Dent J"},{"key":"R6-20250114","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/09537104.2017.1293807","article-title":"Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma","volume":"29","author":"Wang","year":"2018","journal-title":"Platelets"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1179_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:24Z","timestamp":1787837064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1179_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":6,"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1179_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"2024-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}