{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:53:14Z","timestamp":1788468794961,"version":"build-2803163510"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Regeneration of periodontal tissues is an essential component in treating periodontal disease, and there is an increasing focus on biological agents that might improve the healing process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The randomized controlled clinical study included a cohort of 60 individuals diagnosed with chronic periodontitis. Each participant was randomly allocated to one of two groups: the experimental group (n = 30), which underwent PRF in combination with traditional open flap debridement (OFD), and the control group (n = 30), which received OFD alone. Clinical criteria such as probing pocket depth (PPD), clinical attachment level (CAL), and bone fill percentage were assessed at baseline and after 6 months. Furthermore, cone-beam computed tomography (CBCT) was used to evaluate bone regrowth radiographically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Following a period of 6 months, the experimental group had a notable decrease in postpartum depression (mean decrease of 4.2 mm) and an increase in central artery ligation (mean increase of 3.5 mm) compared to the control group, which had a mean decrease in postpartum depression of 2.8 mm and a mean increase in central artery ligation of 2.1 mm. The test group had a notably greater proportion of bone fill (45%) in comparison to the control group (30%). Further radiographic study verified enhanced bone regeneration in the areas treated with PRF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The use of Platelet-Rich Fibrin (PRF) in combination with traditional periodontal surgery greatly expedites the process of periodontal regeneration, as shown by notable enhancements in clinical indicators and bone regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1188_24","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:04:04Z","timestamp":1731481444000},"page":"S3831-S3833","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Platelet-Rich Fibrin (PRF) in Accelerating Periodontal Regeneration: A Randomized Controlled Clinical Trial"],"prefix":"10.4103","volume":"16","author":[{"given":"Ashwini","family":"Dhopte","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konsam Bidya","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental College, JNIMS, Porompat, Imphal, Manipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Pandaw","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maitri Dental College, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Rani","sequence":"additional","affiliation":[{"name":"Maitri College of Dentistry and Research Center, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Chand","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroj","family":"Bagde","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1902\/jop.2011.100731","article-title":"Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects:A randomized clinical trial","volume":"82","author":"Sharma","year":"2011","journal-title":"J Periodontol"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates:From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest","year":"2009","journal-title":"Trends Biotechnol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/ID.0b013e318198cf00","article-title":"The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I:A new grafting protocol","volume":"18","author":"Simonpieri","year":"2009","journal-title":"Implant Dent"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1902\/jop.2016.160443","article-title":"Optimized platelet-rich fibrin with the low-speed concept:Growth factor release, biocompatibility, and cellular response","volume":"88","author":"Fujioka-Kobayashi","year":"2017","journal-title":"J Periodontol"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5624\/isd.2014.44.2.121","article-title":"Does cone-beam CT alter treatment plans?Comparison of preoperative implant planning using panoramic versus cone-beam CT images","volume":"44","author":"Guerrero","year":"2014","journal-title":"Imaging Sci Dent"},{"key":"R6-20241227","first-page":"342","article-title":"Clinical outcomes of periodontal regenerative therapy in intrabony defects:A systematic review","volume":"6","author":"Cortellini","year":"2001","journal-title":"Ann Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1188_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:02Z","timestamp":1787837102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1188_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":6,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1188_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"2024-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}