{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:50Z","timestamp":1787071490019,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The onset of chronic kidney disease (CKD) results in a high level of cardiovascular morbidity and mortality. Conventional risk assessment systems tend to fail in considering the cardiovascular risk of this group of people. A biomarker of myocardial damage, high-sensitivity cardiac troponin I (hs-cTnI), has become a candidate biomarker of subclinical cardiac damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was carried out of 120 patients with CKD stages 3 to 5 that excluded dialysis patients. A high-sensitivity immunoassay was used to measure the baseline value of hs-cTnI. The follow-up was thorough, with patients being kept under observation after 12 months of occurrence in their patients major adverse cardiovascular events (MACE), i.e., myocardial infarction, heart failure hospitalization, and cardiovascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of 120 CKD patients (mean age 58.2+\/- 9.6 years; 62 males), 48 patients (40%) had elevated hs-cTnI (&gt;19.0 ng\/L). The number of patients who developed MACE at the time of the follow-up was 29 (24.2%). There was a significantly greater proportion of MACE in an elevated hs-cTnI group (52.1%) than in a normal hs-cTnI group (10.4%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The Cox regression analysis indicated that an independent outcome predictor of MACE was hs-cTnI (HR 3.89, 95% CI 1.91793,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). The ROC area under the curve of hs-cTnI at predicting MACE was 0.81 (95% CI 0.7290).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>High-sensitivity T-I is a good prognostic biomarker of cardiovascular events among CKD patients. Its regular evaluation can help in the initial classification of risks and selective cardiovascular preventive interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1204_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:02:39Z","timestamp":1766044959000},"page":"S3123-S3125","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of High-Sensitivity Troponin I for Cardiovascular Risk Stratification in Chronic Kidney Disease Patients"],"prefix":"10.4103","volume":"17","author":[{"given":"Mrinal","family":"Kunj","sequence":"first","affiliation":[{"name":"Department of Cardiology, RIMS, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabin Kumar","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Cardiology, RIMS, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, RIMS, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal Tata Medical College, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.hrthm.2019.08.015","article-title":"High-sensitivity troponin and the risk of atrial fibrillation in chronic kidney disease: Results from the chronic renal insufficiency cohort study","volume":"17","author":"Janus","year":"2020","journal-title":"Heart Rhythm"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.amjcard.2019.11.019","article-title":"High sensitivity troponin and risk of incident peripheral arterial disease in chronic kidney disease (from the chronic renal insufficiency cohort [CRIC] study)","volume":"125","author":"Janus","year":"2020","journal-title":"Am J Cardiol"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/00033197211005595","article-title":"Myocardial injury and the risk of stroke in patients with chronic kidney disease (from the chronic renal insufficiency cohort study)","volume":"73","author":"Hajjari","year":"2022","journal-title":"Angiology"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2215\/CJN.01060121","article-title":"Prediction of incident atrial fibrillation in chronic kidney disease: The chronic renal insufficiency cohort study","volume":"16","author":"Zelnick","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1053\/j.ajkd.2020.09.021","article-title":"Change in cardiac biomarkers and risk of incident heart failure and atrial fibrillation in CKD: The chronic renal insufficiency cohort (CRIC) study","volume":"77","author":"Bansal","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"e012200","DOI":"10.1161\/JAHA.119.012200","article-title":"Cardiac biomarkers and risk of atrial fibrillation in chronic kidney disease: The CRIC study","volume":"8","author":"Lamprea-Montealegre","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/CIRCULATIONAHA.112.123992","article-title":"Incident atrial fibrillation and risk of end-stage renal disease in adults with chronic kidney disease","volume":"127","author":"Bansal","year":"2013","journal-title":"Circulation"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1204_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:52Z","timestamp":1787068012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1204_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":7,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1204_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}