{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:07Z","timestamp":1786653667621,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n A common inflammatory condition that damages the tissues that support teeth, chronic periodontitis has become more closely associated with systemic health conditions, especially cardiovascular disease (CVD).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In this randomized controlled experiment, 100 individuals with a diagnosis of chronic periodontitis were included. Two groups of participants were created: a treatment group (\n n<\/jats:italic>\n = 50) that received scaling and root planning as well as other non-surgical periodontal care, and a control group (\n n<\/jats:italic>\n = 50) that did not receive any treatment. Measurements were taken at baseline and 6 months after therapy for systemic inflammatory markers, including as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-\u03b1). The Framingham Risk Score (FRS) was used at the same intervals to evaluate the risk of CVD.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n At 6 months after therapy, patients in the treatment group had substantial reductions in all measured inflammatory markers: CRP was down 30% (\n P<\/jats:italic>\n < 0.01), IL-6 was down 25% (\n P<\/jats:italic>\n < 0.05), and TNF-\u03b1 was down 28% (\n P<\/jats:italic>\n < 0.01). In the therapy group, the Framingham Risk Score dropped by 15% (\n P<\/jats:italic>\n < 0.05), suggesting a lower chance of cardiovascular disease. There were no noteworthy alterations noted in the group under control.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In individuals with persistent periodontitis, non-surgical periodontal treatment may minimize the risk of cardiovascular disease and considerably reduce systemic inflammatory indicators.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1216_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:02:43Z","timestamp":1735257763000},"page":"S3901-S3903","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Periodontal Therapy on Systemic Inflammatory Markers and Cardiovascular Disease Risk in Patients with Chronic Periodontitis"],"prefix":"10.4103","volume":"16","author":[{"given":"Deepti","family":"Shrivastava","sequence":"first","affiliation":[{"name":"Periodontics Division, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah R. F.","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Dental Student, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zayed M. A.","family":"Altimani","sequence":"additional","affiliation":[{"name":"Dental Student, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M.","family":"Alsalem","sequence":"additional","affiliation":[{"name":"Dental Student, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad K.","family":"Alam","sequence":"additional","affiliation":[{"name":"Orthodontic Division, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"},{"name":"Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India"},{"name":"Department of Public Health, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar C.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka, Saudi Arabia"},{"name":"Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"e192523","DOI":"10.1001\/jamanetworkopen.2019.2523","article-title":"Association of childhood oral infections with cardiovascular risk factors and subclinical atherosclerosis in adulthood","volume":"2","author":"Pussinen","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"Suppl 14","key":"R2-20241227","first-page":"S70","article-title":"The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease","volume":"40","author":"Dietrich","year":"2013","journal-title":"J Clin Periodontol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N Engl J Med"},{"issue":"Suppl 14","key":"R4-20241227","first-page":"S85","article-title":"Evidence that periodontal treatment improves biomarkers and CVD outcomes","volume":"40","author":"D'Aiuto","year":"2013","journal-title":"J Clin Periodontol"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1034\/j.1600-051X.2003.00282.x","article-title":"Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses","volume":"30","author":"Ide","year":"2003","journal-title":"J Clin Periodontol"},{"key":"R6-20241227","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N Engl J Med"},{"key":"R7-20241227","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.08-119578","article-title":"Treatment of chronic periodontitis reduces the frequency of circulating CD34+\/KDR+endothelial progenitor cells and modifies cardiovascular risk factors","volume":"23","author":"Piconi","year":"2009","journal-title":"FASEB J"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1216_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:37Z","timestamp":1786650037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1216_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":7,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1216_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-09-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}