{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:14:37Z","timestamp":1789470877476,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    The synthesis of copper nanoparticles (CuNPs) has been the center of researchers\u2019 attention due to their potential in various fields, particularly in medicine and pharmacy. The objective of this research was to synthesize CuNPs by using the extract from\n                    <jats:italic toggle=\"yes\">Polyalthia<\/jats:italic>\n                    longifolia roots via an organic solvent-free approach. The roots of\n                    <jats:italic toggle=\"yes\">P. longifolia<\/jats:italic>\n                    were extracted using boiling water and subsequently used to synthesize CuNPs from CuSO\n                    <jats:sub>4<\/jats:sub>\n                    solution. The resultant nanoparticles were then characterized using UV\u2013Vis spectrophotometer,\n                    <jats:italic toggle=\"yes\">Fourier transform infrared<\/jats:italic>\n                    (FTIR),\n                    <jats:italic toggle=\"yes\">X-ray diffraction<\/jats:italic>\n                    (XRD),\n                    <jats:italic toggle=\"yes\">scanning electron microscope\u2013energy dispersive X-ray<\/jats:italic>\n                    (SEM-EDX), and\n                    <jats:italic toggle=\"yes\">transmission electron microscopy<\/jats:italic>\n                    (TEM). Kirby\u2013Bauer sensitivity test was performed against\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    . In the results, we found that the total phenolic content and total flavonoid content of the extract were 85.43 GAE\/g dry extract and 0.78 QE\/g dry extract, respectively. The characterizations revealed that the obtained nanoparticles possess a spherical shape and diameters of around 2 to 10 nm. The XRD suggests that the nanoparticles were occupied by copper (0) and copper oxides (CuO, CuO\n                    <jats:sub>2<\/jats:sub>\n                    , and Cu\n                    <jats:sub>2<\/jats:sub>\n                    O). The synthesized CuNPs yielded inhibition zones of 17.2 \u00b1 0.2, 15.6 \u00b1 0.2, and 13.7 \u00b1 0.1 mm against\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    , respectively. In conclusion, aqueous extract from the roots of\n                    <jats:italic toggle=\"yes\">P. longifolia<\/jats:italic>\n                    can be used to synthesize CuNPs that could be used as an antibacterial and antifungal agent.\n                  <\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1219_23","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:04:23Z","timestamp":1715731463000},"page":"S2218-S2223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Green Synthesis of Copper Nanoparticles Using Polyalthia longifolia Roots and their Bioactivities Against Escherichia coli, Staphylococcus aureus, and Candida albicans"],"prefix":"10.4103","volume":"16","author":[{"given":"Ilham","family":"Maulana","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binawati","family":"Ginting","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratu A. 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