{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:45Z","timestamp":1787840805686,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>Hypothyroidism significantly alters renal function. Still, there are few scientific studies on thyroid disorders and how it influences renal function. Recent research suggested hypothyroidism may lower the glomerular filtration rate. This study aimed to assess changes in renal function biochemical parameters in MHD patients with primary hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      132 patients with MHD participated in a prospective research who had untreated primary hypothyroidism and euthyroidism. Immunoassay was used to quantify thyroid-stimulating hormone (TSH), free thyroxine (fT\n                      <jats:sub>4<\/jats:sub>\n                      ), and free triiodothyronine (fT\n                      <jats:sub>3<\/jats:sub>\n                      ). Renal parameters; urea and creatinine were measured in fully automated biochemical analyzer and estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease (MDRD) formula.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In comparison with euthyroid MHD patients with primary hypothyroid MHD patients have higher significant values of TSH, creatinine, SBP, DBP as 3.57 \u00b1 1.15 vs 10.49 \u00b1 6.40, 8.23 \u00b1 2.40 vs 9.31 \u00b1 2.49, 155.87 \u00b1 5.84 vs 162 \u00b1 6.82, 91.73 \u00b1 6.14 vs 98.64 \u00b1 6.28. The fT\n                      <jats:sub>4,<\/jats:sub>\n                      fT\n                      <jats:sub>3<\/jats:sub>\n                      and eGFR value reduced significantly in primary hypothyroid MHD patients as compared to euthyroid MHD patients as 1.10 \u00b1 0.24 to 0.44 \u00b1 0.21, 2.65 \u00b1 0.89 to 1.13 \u00b1 0.24 and 6.82 \u00b1 2.5 to 5.40 \u00b1 1.66, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Our study demonstrated that in primary hypothyroid patients due to increase of SBP and DBP glomerular feedback is increased as a result creatinine excretion decreased. So GFR decreased leads to decreased iodine clearance and can cause decreased synthesis of thyroid hormones leading to primary hypothyroidism in MHD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Thyroid dysfunction is linked to impaired kidney function, making it crucial for clinicians to understand this connection in patients with multiple myeloma (MHD), and monitoring creatinine is essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1221_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:06:38Z","timestamp":1738235198000},"page":"S4555-S4558","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Comparative Study of Euthyroid and Primary Hypothyroid Patients in End Stage Renal Disease (ESRD) Undergoing Maintenance Hemodialysis (MHD) in a Tertiary Care Hospital in Salem, Tamil Nadu"],"prefix":"10.4103","volume":"16","author":[{"given":"Chinnathambipalayam Kandasamy","family":"Vijayasamundeeswari","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Vinayaka Mission\u2019s Kirupananda Variyar Medical College and Hospital, Vinayaka Mission\u2019s Research Foundation, Deemed to be University, Salem, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byna","family":"Jayachandrababu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Gannavaram, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip Kumar","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, IQcity Medical College and Hospital, Durgapur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamala Kanta","family":"Parhi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vinayaka Mission\u2019s Kirupananda Variyar Medical College and Hospital, Vinayaka Mission\u2019s Research Foundation, Deemed to be University, Salem, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Jones","family":"Ronald","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Vinayaka Mission\u2019s Kirupananda Variyar Medical College and Hospital, Vinayaka Mission\u2019s Research Foundation, Deemed to be University, Salem, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panneerselvam","family":"Periasamy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Government Erode Medical College, Perundurai, Affiliated Under The Tamil Nadu Dr MGR Medical University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","first-page":"85","article-title":"Thyroid dysfunction in patients with chronic kidney disease undergoing maintenance hemodialysis","volume":"4","author":"Kalasker","year":"2017","journal-title":"Int J Clin Biochem Res"},{"issue":"Suppl 1","key":"R2-20250130","first-page":"S1","volume":"39","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1523-1755.2005.00169.x","article-title":"Increase prevalence of subclinical and clinical hypothyroidism in persons chronic kidney disease","volume":"67","author":"Lo","year":"2005","journal-title":"Kidney Int"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/2230-8210.93737","article-title":"Interactions between thyroid disorders and kidney disease","volume":"16","author":"Basu","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.jrn.2006.07.003","article-title":"Thyroid function, endothelium, and inflammation in hemodialyzed patients:Possible relations?","volume":"17","author":"Malyszko","year":"2007","journal-title":"J Renal Nutr"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"14039","DOI":"10.14260\/jemds\/2015\/1997","article-title":"Comparative study of thyroid abnormalities with severity of chronic renal failure","volume":"4","author":"Shamsuddin","year":"2015","journal-title":"J Evol Med Dent Sci"},{"key":"R7-20250130","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/sj.ki.5001566","article-title":"Low triiodothyronine and survival in end-stage renal disease","volume":"70","author":"Zoccali","year":"2006","journal-title":"Kidney Int"},{"key":"R9-20250130","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/hdi.12527","article-title":"Thyroid function in end stage renal disease and effects of frequent hemodialysis","volume":"21","author":"Lo","year":"2017","journal-title":"Hemodial Int"},{"key":"R10-20250130","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/ndt\/gfu303","article-title":"The relationship between thyroid function and estimated glomerular filtration rate in patients with chronic kidney disease","volume":"30","author":"Rhee","year":"2015","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1221_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:23Z","timestamp":1787837363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1221_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1221_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-09-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}