{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:17Z","timestamp":1787071457289,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Tissue conditioners play a vital role in managing denture stomatitis, but alone may not inhibit\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      , the primary causative organism. Plant-derived agents, like\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Cymene and Triphala, offer antimicrobial benefits with lower resistance risks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Forty-two samples (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 14 per group) were divided into Control,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Cymene, and Triphala groups. Antifungal efficacy was tested via agar diffusion at 24 hours and four days. Hardness, tensile strength, and water sorption were evaluated on day 4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>\n                      Paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test assessed changes over time; one-way ANOVA and Tukey\u2019s HSD were used for intergroup comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Triphala showed the highest antifungal activity at both time points. The control group had the greatest hardness, while tensile strength improved slightly in the Triphala group. Water sorption was lowest in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Incorporation of\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Cymene and Triphala enhanced antifungal efficacy of tissue conditioners, with Triphala being superior, and maintained acceptable mechanical properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1226_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:10Z","timestamp":1766044810000},"page":"S3153-S3155","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation and Comparison of Antifungal Efficacy and Mechanical Properties of Acrylic-based Tissue Conditioner when Incorporated with p-Cymene and Triphala"],"prefix":"10.4103","volume":"17","author":[{"given":"Rajesh","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Yenepoya Dental College and Hospital, Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Lasrado","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Yenepoya Dental College and Hospital, Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar S.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yenepoya Medical College, Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallikarjuna","family":"Ragher","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Yenepoya Dental College and Hospital, Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1532-849X.2011.00698.x","article-title":"Epidemiology and etiology of denture stomatitis","volume":"20","author":"Gendreau","year":"2011","journal-title":"J Prosthodont"},{"key":"R2-20251218","first-page":"75","article-title":"A comparison of the efficacy of nystatin and fluconazole incorporated into tissue conditioner on the in vitro attachment and colonization of Candida albicans","volume":"7","author":"Jafari","year":"2010","journal-title":"Dent Res J (Isfahan)"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/0972-4052.167931","article-title":"A comparative evaluation of effect on water sorption and solubility of a temporary soft denture liner material when stored either in distilled water, 5.25% sodium hypochlorite or artificial saliva: An in vitro study","volume":"16","author":"Garg","year":"2016","journal-title":"J Indian Prosthodont Soc"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"e0272769","DOI":"10.1371\/journal.pone.0273079","article-title":"Synthesis, characterization, and evaluation of the antifungal properties of tissue conditioner incorporated with essential oils-loaded chitosan nanoparticles","volume":"17","author":"Ashraf","year":"2022","journal-title":"PLoS One"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"112282","DOI":"10.1016\/j.fct.2021.112259","article-title":"Health beneficial and pharmacological properties of p-cymene","volume":"153","author":"Balahbib","year":"2021","journal-title":"Food Chem Toxicol"},{"key":"R6-20251218","first-page":"41","article-title":"Study of antimicrobial activity of Triphala and its individual components","volume":"4","author":"Sheta","year":"2016","journal-title":"Int J Herb Med"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.14260\/jemds\/2020\/856","article-title":"Efficacy of anti-fungal agents incorporated in tissue conditioners in inhibiting the growth of candida albicans","volume":"9","author":"Bhat","year":"2020","journal-title":"J Evol Med Dent Sci"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1226_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:23Z","timestamp":1787067983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1226_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":7,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1226_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}