{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:56Z","timestamp":1787071496127,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Gingival recession (GR) is a prevalent periodontal circumstance that may lead to esthetic issues and hypersensitivity of the dentin. New biomaterials, like hyaluronic acid (HA) gel and platelet-rich fibrin (PRF), were developed recently, and they expand the range of opportunities offered by the root coverage procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty patients (aged 25 to 45 years) with bilateral Miller Class 1\/2 recession in the maxillary or mandibular anterior segment were chosen. The study used a split-mouth study design with the left side treated as the test group by using coronally advanced flap (CAF) together with HA gel, and the right side as the control group by using CAF with PRF. Baseline clinical parameters were taken before surgery and six months after surgery as recession depth (RD), clinical attachment level (CAL), and width of keratinized tissue (WKT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was an average RD decrease of 2.4+\/- 0.6 mm in the HA and 2.3+\/- 0.5 mm in the PRF group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.21). CAL gain was 2.6 + 0.5 and 2.5 + 0.4, (HA) and (PRF), respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.34). The HA group had a mean gain of WKT of 1.1 mm (plus or minus 0.3), and the PRF group had a mean gain of WKT of 1.2 mm (plus or minus 0.2) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.15). Both interventions produced large improvements on the baseline but did not differ significantly across the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HA gel and PRF were similarly effective clinically in covering gingival recession, which implies that HA gel could be an adequate substitute of PRF in the treatment of mucogingival procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1228_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:02:04Z","timestamp":1766044924000},"page":"S3135-S3137","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Hyaluronic Acid Gel Versus PRF in Gingival Recession Coverage: A Split-Mouth Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Sourav","family":"Panda","sequence":"first","affiliation":[{"name":"Department of Periodontics, Institute of Dental Sciences, Siksha O Anusandhan University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma Sanjay","family":"Lagdive","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Siddhpur Dental College and Hospital, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirma","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Moti Lal Nehru Medical College, Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aklesha","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhaya Chandra","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Institute of Dental Sciences, Siksha O Anusandhan University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5493\/wjem.v12.i4.68","article-title":"Comparative evaluation of effect of injectable platelet-rich fibrin with collagen membrane compared with collagen membrane alone for gingival recession coverage","volume":"12","author":"Patra","year":"2022","journal-title":"World J Exp Med"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/jisp.jisp_291_20","article-title":"Comparative evaluation of vestibular incision subperiosteal tunnel access with platelet-rich fibrin and connective tissue graft in the management of multiple gingival recession defects: A randomized clinical study","volume":"25","author":"Hegde","year":"2021","journal-title":"J Indian Soc Periodontol"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/jisp.jisp_590_20","article-title":"Minimally invasive treatment of gingival recession by vestibular incision subperiosteal tunnel access technique with collagen membrane and advanced platelet-rich fibrin: A 6-month comparative clinical study","volume":"25","author":"Jain","year":"2021","journal-title":"J Indian Soc Periodontol"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13005-024-00441-1","article-title":"A comparative study of the effects of advanced platelet-rich fibrin and resorbable collagen membrane in the treatment of gingival recession: A split-mouth, randomized clinical trial","volume":"20","author":"Al-Barakani","year":"2024","journal-title":"Head Face Med"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4103\/ccd.ccd_142_17","article-title":"Multiple gingival recession coverage treated with vestibular incision subperiosteal tunnel access approach with or without platelet-rich fibrin-A case series","volume":"8","author":"Garg","year":"2017","journal-title":"Contemp Clin Dent"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"725","DOI":"10.11607\/prd.6101","article-title":"Comparative evaluation of vestibular incision subperiosteal tunnel access (VISTA) technique with and without advanced platelet-rich fibrin for treatment of maxillary anterior gingival recessions","volume":"43","author":"Boddu","year":"2023","journal-title":"Int J Periodontics Restorative Dent"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cap.10257","article-title":"Novel biomaterial advanced platelet-rich fibrin plus block for multiple gingival recession","volume":"14","author":"Mallappa","year":"2024","journal-title":"Clin Adv Periodontics"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"12","DOI":"10.15171\/japid.2019.003","article-title":"Vestibular incisional subperiosteal tunnel access versus coronally advanced flap with connective tissue graft for root coverage of Miller\u2019s class I and II gingival recession: A randomized clinical trial","volume":"11","author":"Mansouri","year":"2019","journal-title":"J Adv Periodontol Implant Dent"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/0976-237X.156034","article-title":"Clinical evaluation and comparison of the efficacy of coronally advanced flap alone and in combination with platelet rich fibrin membrane in the treatment of Miller Class I and II gingival recessions","volume":"6","author":"Gupta","year":"2015","journal-title":"Contemp Clin Dent"},{"key":"R10-20251218","doi-asserted-by":"crossref","first-page":"265","DOI":"10.11607\/prd.2741","article-title":"The Use of Platelet-rich fibrin versus subepithelial connective tissue graft in treatment of multiple gingival recessions: A randomized clinical trial","volume":"37","author":"\u00d6nc\u00fc","year":"2017","journal-title":"Int J Periodontics Restorative Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1228_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:59Z","timestamp":1787068019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1228_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":10,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1228_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}