{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:13Z","timestamp":1787071453556,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n Dental caries remains a prevalent global health issue, particularly among children. Silver diamine fluoride (SDF) is a well-established caries-arresting agent, while nanosilver fluoride (NSF), a newer formulation combining silver nanoparticles and fluoride, offers potential antibacterial and remineralizing benefits. However, comparative evidence on their caries-preventive efficacy remains limited.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A randomized, double-blind, controlled clinical trial was conducted involving 90 caries-active children aged 6 to 9 years. Participants were randomly assigned to three groups (\n n<\/jats:italic>\n = 30 each): Group A received 38% SDF, Group B received NSF, and Group C received distilled water (control). Baseline caries experience was recorded using the DMFS index. Treatments were applied at baseline and after six months. Follow-up examinations were conducted at six and 12 months. Data were analyzed using ANOVA and\n post hoc<\/jats:italic>\n Tukey\u2019s test with significance set at\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n After 12 months, Group A (SDF) showed a mean increment of 0.8 \u00b1 1.2 in DMFS, Group B (NSF) showed 1.1 \u00b1 1.3, and Group C (control) showed 2.7 \u00b1 1.5. The differences between Group A and Group C (\n P<\/jats:italic>\n < 0.001) and between Group B and Group C (\n P<\/jats:italic>\n = 0.003) were statistically significant, while the difference between Group A and Group B was not (\n P<\/jats:italic>\n = 0.217).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Both silver diamine fluoride and nanosilver fluoride were effective in preventing caries progression in high-risk children, with SDF showing marginally better efficacy. NSF appears to be a promising alternative with comparable outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1230_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:15Z","timestamp":1766044815000},"page":"S3156-S3158","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Silver Diamine Fluoride and Nanosilver Fluoride in Preventing Caries: A Comparative Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Priyatam","family":"Karade","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth, (Deemed To Be University) Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Faculty of Dentistry, AIMST University, Semeling-Bedong, Kedah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeti","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Centre for Research and Innovation, Institute of Dental Studies and Technologies, Modinagar, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bismay","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Preventive dentistry, Institute of Dental Sciences, Siksha O Anusandhan (deemed to be) University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashtha","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SGT Dental College, Hospital and Research Institute, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dayananda Sagar College of Dental Sciences, Kumaraswamy layout, Shavige Malleshwara Hills, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jnana Ranjan","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1186\/s12903-024-04406-3","article-title":"Effectiveness of nanosilver fluoride and silver diamine fluoride in arresting early childhood caries: A randomized controlled clinical trial","volume":"24","author":"Quritum","year":"2024","journal-title":"BMC Oral Health"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1186\/s12903-023-03597-5","article-title":"Silver diamine fluoride with sodium fluoride varnish versus silver diamine fluoride in arresting early childhood caries: A 6-months follow up of a randomized field trial","volume":"23","author":"Abdellatif","year":"2023","journal-title":"BMC Oral Health"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"104878","DOI":"10.1016\/j.jdent.2024.104878","article-title":"Effect of silver diamine fluoride and nano silver fluoride on oral health-related quality of life of children with early childhood caries: A randomized clinical trial","volume":"142","author":"Quritum","year":"2024","journal-title":"J Dent"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1186\/s12903-023-03456-3","article-title":"Effectiveness of silver diamine fluoride versus sodium fluoride varnish combined with mother\u2019s motivational interviewing for arresting early childhood caries: A randomized clinical trial","volume":"23","author":"Yassin","year":"2023","journal-title":"BMC Oral Health"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1186\/s12903-022-02697-y","article-title":"Antibacterial effect and impact on caries activity of nanosilver fluoride and silver diamine fluoride in dentin caries of primary teeth: A randomized controlled clinical trial","volume":"22","author":"Ammar","year":"2022","journal-title":"BMC Oral Health"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"103375","DOI":"10.1016\/j.jdent.2020.103375","article-title":"A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride","volume":"99","author":"Mabangkhru","year":"2020","journal-title":"J Dent"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1186\/s12903-024-04791-9","article-title":"An open-label, parallel-group, randomized clinical trial of different silver diamine fluoride application intervals to arrest dental caries","volume":"24","author":"Schroth","year":"2024","journal-title":"BMC Oral Health"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13063-020-4088-7","article-title":"Preventing early childhood caries with silver diamine fluoride: Study protocol for a randomised clinical trial","volume":"21","author":"Gao","year":"2020","journal-title":"Trials"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.adaj.2024.02.013","article-title":"Using sequential applications of a novel silver diamine fluoride gel and sodium fluoride varnish to arrest severe early childhood caries lesions: A clinical trial with single group assignment","volume":"155","author":"Padilla","year":"2024","journal-title":"J Am Dent Assoc"},{"key":"R10-20251218","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jdent.2017.12.013","article-title":"Caries arrest by topical fluorides in preschool children: 30-month results","volume":"70","author":"Duangthip","year":"2018","journal-title":"J Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1230_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:19Z","timestamp":1787067979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1230_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":10,"journal-issue":{"issue":"Suppl 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