{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:12Z","timestamp":1787071452991,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n Injectable platelet-rich fibrin (i-PRF) has emerged as a bioactive material in periodontal regeneration due to its rich content of growth factors and ease of application. However, its clinical efficacy in managing intrabony defects remains underexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To evaluate the clinical and radiographic outcomes of intrabony defect treatment using i-PRF in comparison with open flap debridement (OFD) alone.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This randomized controlled clinical trial included 40 patients with chronic periodontitis presenting with intrabony defects, divided into two groups: Group A (OFD + i-PRF) and Group B (OFD only). Clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth were measured at baseline and 6 months postoperatively. Intraoral periapical radiographs with a customized grid and paralleling technique were used for radiographic evaluation. Statistical analysis was performed using paired and unpaired\n t<\/jats:italic>\n -tests with a significance threshold of\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n At 6 months, Group A showed significantly greater PPD reduction (3.46 \u00b1 0.62 mm) compared with Group B (2.12 \u00b1 0.54 mm,\n P<\/jats:italic>\n < 0.001). CAL gain was also significantly higher in Group A (3.12 \u00b1 0.58 mm) versus Group B (1.78 \u00b1 0.61 mm,\n P<\/jats:italic>\n < 0.001). Radiographic bone fill was 58.4% \u00b1 9.7% in Group A compared with 34.6% \u00b1 8.3% in Group B (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The adjunctive use of injectable PRF with OFD demonstrated superior clinical and radiographic improvements in the treatment of intrabony defects compared to OFD alone, suggesting its promising role in periodontal regeneration.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1271_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:11Z","timestamp":1766044811000},"page":"S3171-S3173","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Radiographic Assessment of Injectable Platelet-Rich Fibrin in the Treatment of Intrabony Defects"],"prefix":"10.4103","volume":"17","author":[{"given":"E.","family":"Amuthavalli","sequence":"first","affiliation":[{"name":"Department of Dental Surgery, KAPV Medical College, Trichy, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balamurugan","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, Government Medical College, Virudhunagar, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jareen Abdul","family":"Jafeer","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan","year":"2009","journal-title":"Trends Biotechnol"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1563\/aaid-joi-D-14-00138","article-title":"Advanced platelet-rich fibrin: A new concept for cell-based tissue engineering by means of inflammatory cells","volume":"40","author":"Ghanaati","year":"2014","journal-title":"J Oral Implantol"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1902\/jop.2016.160443","article-title":"Optimized platelet-rich fibrin with the low-speed concept: Growth factor release, biocompatibility, and cellular response","volume":"88","author":"Fujioka-Kobayashi","year":"2017","journal-title":"J Periodontol"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tripleo.2009.02.007","article-title":"Platelet-rich plasma and platelet-rich fibrin in human cell culture","volume":"108","author":"Gassling","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tripleo.2009.06.044","article-title":"A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro","volume":"108","author":"He","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00784-016-1719-1","article-title":"Comparative release of growth factors from PRP, PRF, and advanced-PRF","volume":"20","author":"Kobayashi","year":"2016","journal-title":"Clin Oral Investig"},{"key":"R7-20251218","first-page":"1717","article-title":"Efficacy of platelet-rich fibrin and zinc\u2013hydroxyapatite in the treatment of intrabony defects: A randomized clinical trial","volume":"84","author":"Pradeep","year":"2013","journal-title":"J Periodontol"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s11999-015-4192-2","article-title":"Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro","volume":"473","author":"Sch\u00e4r","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"R9-20251218","first-page":"101","article-title":"Treatment of human periodontal defects using autologous platelet-rich fibrin: A prospective cohort study","volume":"6","author":"Kobayashi","year":"2016","journal-title":"Clin Adv Periodontics"},{"key":"R10-20251218","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00784-019-02981-2","article-title":"A novel method for evaluating fibrin clot degradation in vitro","volume":"24","author":"Miron","year":"2020","journal-title":"Clin Oral Investig"},{"key":"R11-20251218","first-page":"638043","article-title":"Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation","volume":"2013","author":"Li","year":"2013","journal-title":"Biomed Res Int"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1271_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:20Z","timestamp":1787067980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1271_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":11,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1271_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}