{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:15Z","timestamp":1787071455124,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Abnormal uterine bleeding (AUB), particularly heavy menstrual bleeding (HMB), significantly impairs women\u2019s health and quality of life. Levonorgestrel intrauterine system (LNG-IUS) offers a uterus-sparing alternative to surgical interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of LNG-IUS in the long-term management of AUB unrelated to intrauterine pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted on 30 parous women aged 33-48 years with recurrent HMB. LNG-IUS was inserted within 7 days of menstruation onset, and patients were followed at 1, 3, 6, 12, and 24 months. Bleeding intensity and side effects were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of 30 patients, 21 (70%) reported a significant reduction in bleeding. Only 9 patients (30%) required a hysterectomy. Mild side effects were reported in 33.3% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LNG-IUS is an effective, well-tolerated, long-term treatment for AUB and can reduce the need for hysterectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1273_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:23Z","timestamp":1766044823000},"page":"S3177-S3179","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Role of Levonorgestrel Intrauterine System (LNG-IUS) in the Management of Abnormal Uterine Bleeding (AUB): A Conservative Approach to Preserve the Uterus"],"prefix":"10.4103","volume":"17","author":[{"given":"Jagrati Kiran","family":"Naagar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Bundelkhand Government Medical College, Sagar, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Bundelkhand Government Medical College, Sagar, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitu","family":"Mishra","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit, Bundelkhand Government Medical College, Sagar, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopali","family":"Jain","sequence":"additional","affiliation":[{"name":"Private Practitioner, Sagar, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2010.11.011","article-title":"FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age","volume":"113","author":"Munro","year":"2011","journal-title":"Int J Gynaecol Obstet"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/bmj.316.7138.1122","article-title":"Open randomised study of use of levonorgestrel releasing intrauterine system as alternative to hysterectomy","volume":"316","author":"L\u00e4hteenm\u00e4ki","year":"1998","journal-title":"BMJ"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/AOG.0b013e3181a1d3ce","article-title":"Levonorgestrel-releasing intrauterine system and endometrial ablation in heavy menstrual bleeding: A systematic review and meta-analysis","volume":"113","author":"Kaunitz","year":"2009","journal-title":"Obstet Gynecol"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1056\/NEJMoa1204724","article-title":"Levonorgestrel intrauterine system versus medical therapy for menorrhagia","volume":"368","author":"Gupta","year":"2013","journal-title":"N Engl J Med"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(00)03615-1","article-title":"Quality of life and cost-effectiveness of levonorgestrel-releasing intrauterine system versus hysterectomy for treatment of menorrhagia: A randomised trial","volume":"357","author":"Hurskainen","year":"2001","journal-title":"Lancet"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijgo.2011.07.031","article-title":"Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma","volume":"116","author":"Kriplani","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2165\/11598960-000000000-00000","article-title":"The levonorgestrel-releasing intrauterine system in heavy menstrual bleeding: A benefit-risk review","volume":"72","author":"Kaunitz","year":"2012","journal-title":"Drugs"},{"key":"R8-20251218","article-title":"Heavy Menstrual Bleeding: Assessment and Management","year":"2018"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/humupd\/dmi046","article-title":"New progestagens for contraceptive use","volume":"12","author":"Sitruk-Ware","year":"2006","journal-title":"Hum Reprod Update"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1273_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:23Z","timestamp":1787067983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1273_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1273_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}