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A cluster of six Listeria monocytogenes bacteremia was noted within 10 months at a tertiary care referral center. Patients were 27-72 years old; four also had concomitant immunosuppressive diseases, including chronic renal disease, diabetes mellitus, and cancer. All the infections were confirmed on blood culture performed with the VITEK 2 system. The organisms were all gentamicin and ampicillin-sensitive. Five patients improved on intravenous antibiotic therapy, and one died from multiorgan failure. The series reiterates the importance of maintaining listeriosis as a significant concern in febrile patients with predisposing conditions. 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