{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:18Z","timestamp":1787071458528,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n Sutures are essential for wound closure but may facilitate microbial colonization, increasing the risk of surgical site infections. Antibacterial-coated sutures, such as triclosan (TCS) and chlorhexidine (CCS), have been developed to mitigate this concern.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A double-blind, randomized clinical trial was conducted on 20 patients undergoing periodontal flap surgery, comparing TCS and CCS. Healing was assessed on postoperative day 8 using Landry\u2019s Healing Index; microbial burden was quantified through CFU enumeration and Gram staining.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Healing scores were comparable between groups (TCS: 4.1 \u00b1 0.7; CCS: 3.9 \u00b1 0.7;\n P<\/jats:italic>\n = 0.63). However, CCS exhibited significantly lower CFU counts (0.011 \u00d7 10\n 6<\/jats:sup>\n \u00b1 0.031 \u00d7 10\n 6<\/jats:sup>\n ) than TCS (4.3 \u00d7 10\n 6<\/jats:sup>\n \u00b1 4.8 \u00d7 10\n 6<\/jats:sup>\n ) (\n P<\/jats:italic>\n < 0.001). Gram staining revealed polymicrobial oral flora in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Chlorhexidine-coated sutures exhibited superior antimicrobial efficacy without compromising early wound healing.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1288_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:40Z","timestamp":1766044840000},"page":"S3214-S3216","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of the Efficacy of Triclosan-Coated and Chlorhexidine-Coated Suture on Bacterial Load Reduction in Periodontal Flap Surgery: A Clinicomicrobiological Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Megha","family":"Choudhary","sequence":"first","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroj","family":"Bagde","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N.","family":"Savitha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oxford Dental College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrishali","family":"Radke","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Gayatri Dental Clinic, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0196-6553(99)70088-X","article-title":"Guideline for prevention of surgical site infection, 1999. Centers for disease control and prevention (CDC) hospital infection control practices advisory committee","volume":"27","author":"Mangram","year":"1999","journal-title":"Am J Infect Control"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"138","DOI":"10.9734\/jpri\/2020\/v32i1930720","article-title":"Comparing the efficacy of triclosan-coated sutures versus chlorhexidine-coated sutures in preventing surgical site infection after removal of impacted mandibular third molar","volume":"32","author":"Krishnan","year":"2020","journal-title":"J Pharm Res Int"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/odi.12001","article-title":"Triclosan alters antimicrobial and inflammatory responses of epithelial cells","volume":"19","author":"Wallet","year":"2013","journal-title":"Oral Dis"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7324\/JAPS.2019.90716","article-title":"Drug-eluting sutures: A recent update","volume":"9","author":"Anureet","year":"2019","journal-title":"J Appl Pharm Sci"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3389\/fmicb.2014.00780","article-title":"The impact of triclosan on the spread of antibiotic resistance in the environment","volume":"5","author":"Carey","year":"2015","journal-title":"Front Microbiol"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/jisp.jisp_524_18","article-title":"Comparative evaluation of two antibacterial-coated resorbable sutures versus noncoated resorbable sutures in periodontal flap surgery: A clinico-microbiological study","volume":"23","author":"Karde","year":"2019","journal-title":"J Indian Soc Periodontol"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10096-016-2765-y","article-title":"Antimicrobial-coated sutures to decrease surgical site infections: A systematic review and meta-analysis","volume":"36","author":"Wu","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R8-20251218","first-page":"267","article-title":"Polyglactin 910 vs. triclosan-coated polyglactin 910 in oral surgery: A comparative in vivo study","volume":"4","author":"Kruthi","year":"2014","journal-title":"Dentistry"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/28970","article-title":"Triclosan targets lipid synthesis","volume":"394","author":"McMurry","year":"1998","journal-title":"Nature"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1288_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:26Z","timestamp":1787067986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1288_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1288_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}