{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:29Z","timestamp":1787772149760,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To estimate and compare the level of serum immunoglobulin A in patients of oral submucous fibrosis (OSMF), leukoplakia, and control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>OSMF is a well-recognized potentially malignant condition in the oral cavity, and a transformation rate as high as 7.6% over a period of 10 years has been reported from India. Leukoplakia has evolved as a clinico-pathologic concept over many years, with the current clinical designation being accepted worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Quantia IgA is a turbidometric immunoassay for the detection of IgA in human serum and is based on the principle of agglutination reaction. The test specimen is mixed with the activation buffer (R1) and then with antihuman IgA reagent (R2) and allowed to react. For the estimation of serum IgA, 500 \u03bcl of Quantia IgA activation buffer R1 is taken in a clean test tube. Serum sample is diluted in the ratio of 1:5 with normal saline. Ten microliters of diluted serum sample are added to R1. After incubation for 10 min, 50 \u03bcl of R2 is added, which is Quantia IgA antihuman IgA reagent to the sample, and the reading is recorded at wavelength 340 nm at 37\u00b0C. The level of IgA will be estimated by a semi-automatic biochemical analyzer machine and then data analysis will be done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The immunologic alterations observed by us in OSMF and leukoplakia are almost similar or nearer to the alterations observed in oral cancer, so it is reasonable to assume that OSMF and leukoplakia can be an intermediate stage in the transformation process of a normal cell to oral malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prevention and early detection is the best way to reduce the incidence and mortality of premalignant disorders and oral cancer. There are many ways and methods of early detection of premalignant disorders and oral cancer, and the immunological method is one of them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1295_23","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T12:01:04Z","timestamp":1712750464000},"page":"S1987-S1990","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["To Estimate and Compare the Level of Serum Immunoglobulin A in Patients of Oral Submucous Fibrosis, Leukoplakia, and Control Group"],"prefix":"10.4103","volume":"16","author":[{"given":"Sweta Prakash","family":"Shele","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Rural Dental College, PIMS, Loni, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja P","family":"Bhagwat","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, VYWS Dental College, Amravati, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Yadav","sequence":"additional","affiliation":[{"name":"Assistant Professor, Oral Pathology and Microbiology, MGV\u2019s KBH Dental College and Hospital, Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, VYWS Dental College, Amravati, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Ghaisas","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, MGM Dental College and Hospital, Kamothe, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwesha","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department 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