{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:38Z","timestamp":1786649438067,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder associated with autonomic nervous system (ANS) dysregulation, potentially increasing cardiometabolic risk.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n This case-control study aimed to compare heart rate variability (HRV), a non-invasive measure of ANS function, in women with and without PCOS.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n A total of 100 women (50 with PCOS and 50 age- and BMI-matched controls) aged 18\u201345 years were recruited at SRM Medical College Hospital and Research Centre. HRV was assessed using time-domain (SDNN, RMSSD, NN50, pNN50) and frequency-domain (VLF, LF, HF, LF\/HF ratio) parameters.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Women with PCOS exhibited significantly reduced HRV, with lower SDNN (32.4 \u00b1 8.1 ms vs. 42.7 \u00b1 9.3 ms,\n P<\/jats:italic>\n < 0.001), RMSSD (25.6 \u00b1 7.2 ms vs. 35.8 \u00b1 8.5 ms,\n P<\/jats:italic>\n < 0.001), and HF power (28.1 \u00b1 6.3% vs. 36.4 \u00b1 7.9%,\n P<\/jats:italic>\n < 0.01), indicating reduced parasympathetic activity and autonomic imbalance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n These findings suggest that women with PCOS may have an increased risk of cardiometabolic complications due to autonomic dysfunction. Early HRV assessment could serve as a non-invasive tool for identifying at-risk individuals.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1295_25","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:00:18Z","timestamp":1766422818000},"page":"227-229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Heart Rate Variability in Women with and Without Polycystic Ovary Syndrome (PCOS)"],"prefix":"10.4103","volume":"17","author":[{"given":"Sivaranjani","family":"Sarathivarman","sequence":"first","affiliation":[{"name":"Department of Physiology, SRM Medical College, Hospital and Research Center, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhavathi","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Physiology, SRM Medical College, Hospital and Research Center, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthi","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Physiology, SRM Medical College, Hospital and Research Center, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavisha Sreenivasan","family":"Leelabai","sequence":"additional","affiliation":[{"name":"Department of Physiology, SRM Medical College, Hospital and Research Center, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamarai Selvi","family":"Kanagaraj","sequence":"additional","affiliation":[{"name":"Department of Physiology, SRM Medical College, Hospital and Research Center, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Ayyavoo","sequence":"additional","affiliation":[{"name":"Department of Physiology, SRM Medical College, Hospital and Research Center, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panneerselvam","family":"Periasamy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Government Erode Medical College, Perundurai, Erode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"R1-20251223","doi-asserted-by":"crossref","first-page":"e0028","DOI":"10.1097\/pp9.0000000000000028","article-title":"Cross-sectional study on the knowledge and prevalence of PCOS at a Multiethnic University","volume":"5","author":"Rao","year":"2020","journal-title":"Prog Prev 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Sci"},{"key":"R5-20251223","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.fertnstert.2008.12.024","article-title":"The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome","volume":"93","author":"Nafiye","year":"2010","journal-title":"Fertil Steril"},{"key":"R6-20251223","first-page":"a450","article-title":"The contribution of hyperinsulinemia to hyperandrogenism of polycystic ovary syndrome","volume":"4","author":"Pateguana","year":"2019","journal-title":"J Insul Resist"},{"key":"R7-20251223","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.3390\/ijms21218191","article-title":"Sex hormone-binding globulin (SHBG) as an early biomarker and therapeutic target in polycystic ovary syndrome","volume":"21","author":"Qu","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1295_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:11Z","timestamp":1786647251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1295_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1295_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-07-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}