{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:33:37Z","timestamp":1786736017581,"version":"build-2736575974"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharm Bioall Sci"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/jpbs.jpbs_12_18","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T03:32:24Z","timestamp":1535599944000},"page":"119","source":"Crossref","is-referenced-by-count":21,"title":["An insight and update on the analgesic properties of vitamin C"],"prefix":"10.4103","volume":"10","author":[{"given":"NallanCSK","family":"Chaitanya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Muthukrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CMS","family":"Krishnaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gali","family":"Sanjuprasanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poojaragini","family":"Pillay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balmoori","family":"Mounika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0975-7406.240115-1","unstructured":"International Association for the Study of Pain. IASP taxonomy by task force on taxonomy. 2014. Available from: https:\/\/www.iasp-pain.org\/Education\/Content.aspx?ItemNumber=1698#Pain."},{"key":"key-10.4103\/0975-7406.240115-2","unstructured":"WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Classification of pain in children. Available from: http:\/\/apps.who.int\/iris\/bitstream\/10665\/44540\/1\/9789241548120_Guidelines.pdf."},{"key":"key-10.4103\/0975-7406.240115-3","first-page":"209","volume-title":"Can vitamin C be used as an adjuvant for managing postoperative pain.A short literature review?","author":"Hasanzadeh","year":"2013","journal-title":"Korean J Pain"},{"key":"key-10.4103\/0975-7406.240115-4","first-page":"179","volume-title":"Effect of perioperative vitamin C supplementation on postoperative pain and the incidence of chronic regional pain syndrome: a systematic review and meta-analysis","author":"Chen","year":"2016","journal-title":"Clin J Pain"},{"key":"key-10.4103\/0975-7406.240115-5","first-page":"535","volume-title":"Relationship between nurses\u2019 pain knowledge and pain management outcomes for their postoperative cardiac patients","author":"Watt-Watson","year":"2001","journal-title":"J Adv Nurs"},{"key":"key-10.4103\/0975-7406.240115-6","doi-asserted-by":"crossref","unstructured":"MacLellan K. Postoperative pain: strategy for improving patient experiences. J Adv Nur 2004;10:179-85.","DOI":"10.1111\/j.1365-2648.2003.02977.x"},{"key":"key-10.4103\/0975-7406.240115-7","first-page":"S1","volume-title":"Perioperative pain management in hip and knee replacement surgery","author":"Barrington","year":"2014","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"key-10.4103\/0975-7406.240115-8","first-page":"715","volume-title":"The economic costs of pain in the United States","author":"Gaskin","year":"2012","journal-title":"J Pain"},{"key":"key-10.4103\/0975-7406.240115-9","first-page":"971","volume-title":"Pain mechanisms: a new theory","author":"Melzack","year":"1965","journal-title":"Science"},{"key":"key-10.4103\/0975-7406.240115-10","first-page":"677","volume-title":"A study of intravenous administration of vitamin C in the treatment of acute herpetic pain and postherpetic neuralgia","author":"Kim","year":"2016","journal-title":"Ann Dermatol"},{"key":"key-10.4103\/0975-7406.240115-11","first-page":"CR215","volume-title":"Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study","author":"Schencking","year":"2012","journal-title":"Med Sci Monit"},{"key":"key-10.4103\/0975-7406.240115-12","first-page":"562","volume-title":"Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain","author":"Chen","year":"2009","journal-title":"Clin J Pain"},{"key":"key-10.4103\/0975-7406.240115-13","first-page":"465","volume-title":"Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: a systematic review and meta-analysis","author":"A\u00efm","year":"2017","journal-title":"Orthop Traumatol Surg Res"},{"key":"key-10.4103\/0975-7406.240115-14","first-page":"179","volume-title":"Effect of vitamin C on prevention of complex regional pain syndrome type I in foot and ankle surgery","author":"Besse","year":"2009","journal-title":"Foot Ankle Surg"},{"key":"key-10.4103\/0975-7406.240115-15","first-page":"1","volume-title":"Effect of intravenous high dose vitamin C on postoperative pain and morphine use after laparoscopic colectomy: a randomized controlled trial","author":"Jeon","year":"2016","journal-title":"Pain Res Manage"},{"key":"key-10.4103\/0975-7406.240115-16","unstructured":"Vitamin C. Human vitamin and mineral requirements. FAO corporate document repository. Available from: http:\/\/www.fao.org\/docrep\/004\/y2809e\/y2809e0c.htm."},{"key":"key-10.4103\/0975-7406.240115-17","first-page":"213","volume-title":"Vitamin C: biosynthesis, evolutionary significance and biological function","author":"Chatterjee","year":"1998","journal-title":"PINSA"},{"key":"key-10.4103\/0975-7406.240115-18","first-page":"18","volume-title":"Vitamin C as an antioxidant: evaluation of its role in disease prevention","author":"Padayatty","year":"2003","journal-title":"J Am Coll Nutr"},{"key":"key-10.4103\/0975-7406.240115-19","first-page":"437","volume-title":"Biosynthesis of ascorbic acid in plants: a renaissance","author":"Smirnoff","year":"2001","journal-title":"Annu Rev Plant Physiol Plant Mol Biol"},{"key":"key-10.4103\/0975-7406.240115-20","first-page":"241","volume-title":"L-ascorbic acid biosynthesis","author":"Smirnoff","year":"2001","journal-title":"Vitam Horm"},{"key":"key-10.4103\/0975-7406.240115-21","first-page":"81","volume-title":"Biological role of vitamin C in keratinocytes","author":"Catani","year":"2005","journal-title":"Nutr Rev"},{"key":"key-10.4103\/0975-7406.240115-22","first-page":"66","volume-title":"Vitamin C function and status in chronic disease","author":"Jacob","year":"2002","journal-title":"Nutr Clin Care"},{"key":"key-10.4103\/0975-7406.240115-23","first-page":"313","volume-title":"Vitamin C (ascorbic acid): new roles, new requirements?","author":"Gershoff","year":"1993","journal-title":"Nutr Rev"},{"key":"key-10.4103\/0975-7406.240115-24","first-page":"507","volume-title":"Regulatory role of vitamins E and C on extracellular matrix components of the vascular system","author":"Villacorta","year":"2007","journal-title":"Mol Aspects Med"},{"key":"key-10.4103\/0975-7406.240115-25","first-page":"2068","volume-title":"Role of vitamin C in the function of the vascular endothelium","author":"May","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"key-10.4103\/0975-7406.240115-26","first-page":"17281","volume-title":"Ascorbic acid induces alkaline phosphatase, type X collagen, and calcium deposition in cultured chick chondrocytes","author":"Leboy","year":"1989","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0975-7406.240115-27","first-page":"1336","volume-title":"Ascorbic acid accelerates osteoclast formation and death","author":"Le","year":"2010","journal-title":"Bone"},{"key":"key-10.4103\/0975-7406.240115-28","first-page":"915","volume-title":"A crucial role for thiol antioxidants in estrogen-deficiency bone loss","author":"Lean","year":"2003","journal-title":"J Clin Invest"},{"key":"key-10.4103\/0975-7406.240115-29","unstructured":"Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press; 2000."},{"key":"key-10.4103\/0975-7406.240115-30","first-page":"637","volume-title":"Dietary reference intakes for the antioxidant nutrients: vitamin C, vitamin E, selenium, and carotenoids","author":"Monsen","year":"2000","journal-title":"J Am Diet Assoc"},{"key":"key-10.4103\/0975-7406.240115-31","first-page":"445","volume-title":"Old world meets modern: a case report of scurvy","author":"Wang","year":"2007","journal-title":"Nutr Clin Pract"},{"key":"key-10.4103\/0975-7406.240115-32","first-page":"1086","volume-title":"Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans","author":"Carr","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"key-10.4103\/0975-7406.240115-33","first-page":"261","volume-title":"Scurvy masquerading as leukocytoclastic vasculitis: a case report and review of the literature","author":"Francescone","year":"2005","journal-title":"Cutis"},{"key":"key-10.4103\/0975-7406.240115-34","first-page":"848","volume-title":"Therapeutic basis of clinical pain modulation","author":"Kirkpatrick","year":"2015","journal-title":"Clin Transl Sci"},{"key":"key-10.4103\/0975-7406.240115-35","doi-asserted-by":"crossref","unstructured":"Dionne CE, Laurin D, Desrosiers T, Abdous B, Le Sage N, Frenette J, et al. Serum vitamin C and spinal pain: a nationwide study. Pain 2016;10:2527-35.","DOI":"10.1097\/j.pain.0000000000000671"},{"key":"key-10.4103\/0975-7406.240115-36","first-page":"535","volume-title":"The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate","author":"Buettner","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"key-10.4103\/0975-7406.240115-37","first-page":"1007","volume-title":"Does vitamin C act as a pro-oxidant under physiological conditions?","author":"Carr","year":"1999","journal-title":"FASEB J"},{"key":"key-10.4103\/0975-7406.240115-38","first-page":"108","volume-title":"Administration of vitamin C in a patient with herpes zoster: a case report","author":"Byun","year":"2011","journal-title":"Korean J Pain"},{"key":"key-10.4103\/0975-7406.240115-39","first-page":"551","volume-title":"The vitamin C controversy","author":"Peek","year":"2010","journal-title":"Clin J Pain"},{"key":"key-10.4103\/0975-7406.240115-40","first-page":"1424","volume-title":"Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures.A randomized, controlled, multicenter dose\u2013response study?","author":"Zollinger","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"key-10.4103\/0975-7406.240115-41","first-page":"1616","volume-title":"Treatment of postherpetic neuralgia with intravenous administration of vitamin C","author":"Chen","year":"2006","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0975-7406.240115-42","first-page":"2563","volume-title":"[Reduced pain from osteoarthritis in hip joint or knee joint during treatment with calcium ascorbate.A randomized, placebo-controlled cross-over trial in general practice]","author":"Jensen","year":"2003","journal-title":"Ugeskr Laeger"},{"key":"key-10.4103\/0975-7406.240115-43","first-page":"57","volume-title":"Parenteral vitamin C relieves chronic fatigue and pain in a patient presenting with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis","author":"Carr","year":"2015","journal-title":"Case Rep Clin Path"},{"key":"key-10.4103\/0975-7406.240115-44","first-page":"151","volume-title":"Ascorbic acid as a chemotherapeutic agent","author":"McCormick","year":"1952","journal-title":"Arch Pediatr"},{"key":"key-10.4103\/0975-7406.240115-45","first-page":"3685","volume-title":"Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer","author":"Cameron","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"key-10.4103\/0975-7406.240115-46","first-page":"92","volume-title":"A community-based study of vitamin C (ascorbic acid) in patients with advanced cancer","author":"Tschetter","year":"1983","journal-title":"Proc Am Soc Clin Oncol"},{"key":"key-10.4103\/0975-7406.240115-47","first-page":"137","volume-title":"High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy.A randomized double-blind comparison","author":"Moertel","year":"1985","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0975-7406.240115-48","first-page":"103","volume-title":"Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate","author":"Murata","year":"1982","journal-title":"Int J Vitam Nutr Res Suppl"},{"key":"key-10.4103\/0975-7406.240115-49","doi-asserted-by":"crossref","unstructured":"Cameron E, Campbell A. The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer. Chem Biol Interact 1974;10:285-315.","DOI":"10.1016\/0009-2797(74)90019-2"},{"key":"key-10.4103\/0975-7406.240115-50","first-page":"365","volume-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"key-10.4103\/0975-7406.240115-51","first-page":"7","volume-title":"Changes of terminal cancer patients\u2019 health-related quality of life after high dose vitamin C administration","author":"Yeom","year":"2007","journal-title":"J Korean Med Sci"},{"key":"key-10.4103\/0975-7406.240115-52","first-page":"49","volume-title":"High-dose intravenous vitamin C improves quality of life in cancer patients","author":"Takahashi","year":"2012","journal-title":"Personalized Med Universe"},{"key":"key-10.4103\/0975-7406.240115-53","first-page":"139","volume-title":"Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer","author":"Stephenson","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"key":"key-10.4103\/0975-7406.240115-54","first-page":"84","volume-title":"Parenteral vitamin C for palliative care of terminal cancer patients","author":"Carr","year":"2014","journal-title":"N Z Med J"},{"key":"key-10.4103\/0975-7406.240115-55","first-page":"747","volume-title":"The role of vitamin C in epigenetic regulation","author":"Guz","year":"2017","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"key-10.4103\/0975-7406.240115-56","first-page":"e0177074","volume-title":"The association of dietary vitamin C intake with periodontitis among Korean adults: results from KNHANES \u2163","author":"Lee","year":"2017","journal-title":"PLoS One"},{"key":"key-10.4103\/0975-7406.240115-57","first-page":"152","volume-title":"Clinical management and control of alveolalgia (\u201cdry socket\u201d) with vitamin C","author":"Halberstein","year":"2003","journal-title":"Am J Dent"}],"container-title":["Journal of Pharmacy And Bioallied Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:36:11Z","timestamp":1786732571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JPBS.JPBS_12_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"alternative-id":["240115"],"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_12_18","relation":{},"ISSN":["0975-7406"],"issn-type":[{"value":"0975-7406","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}