{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:14Z","timestamp":1787775854498,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Combined endo-perio lesions (CEPLs) are one of the toughest problems in clinical dentistry because of complex causative factors and multi-rooted anatomical structures. As a result, the treatment outcome using a conventional approach is often erratic and unpredictable. This study investigated the efficacy of 3D-printed scaffolds in guided tissue regeneration (GTR) for managing CEPLs, utilizing a combined clinical and radiographic assessment approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This prospective clinical trial enrolled patients diagnosed with CEPLs. Following endodontic treatment, the lesions were randomly assigned to either a test group (3D-printed scaffold + GTR) or a control group (GTR alone). Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and gingival recession (GR), were recorded at baseline, 3 months, 6 months, and 12 months postoperatively. Radiographic assessments, including bone fill and defect resolution, were performed using cone-beam computed tomography (CBCT) at the same time intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The test group demonstrated statistically significant improvements in all clinical parameters (PD, CAL, GR) compared to the control group at all follow-up periods (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Radiographic analysis revealed significantly enhanced bone fill and defect resolution in the test group compared to the control group at all time points (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>3d-printed scaffolds in GTR exhibited superior clinical and radiographic outcomes compared to conventional GTR alone in the treatment of CEPLs. The 3D-printed scaffolds promoted enhanced tissue regeneration and bone formation, contributing to improved periodontal healing and defect resolution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_12_25","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:00:36Z","timestamp":1746849636000},"page":"S568-S570","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of 3D-Printed Scaffolds in Guided Tissue Regeneration for Combined Endo-Perio Lesions: A Clinical and Radiographic Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Anuj Singh","family":"Parihar","sequence":"first","affiliation":[{"name":"Department of Periodontology, People\u2019s Dental Academy, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimisha","family":"Nandanan","sequence":"additional","affiliation":[{"name":"BDS, MDS in Periodontics and Implantology, PhD Scholar, Periodontist, Shri Vinobha Bhave Civil Hospital, Silvassa, Dadra and Nagar Haveli, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiren H.","family":"Patadiya","sequence":"additional","affiliation":[{"name":"My Dental Southbridge, Southbridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meetu","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Periodontics, R.R. Dental College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dr. RR Kambe Dental College and Hospital, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"R1-20250513","first-page":"119404","article-title":"Poly (ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery applications","volume":"221","author":"Aimetti","year":"2019","journal-title":"Biomaterials"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nmat4489","article-title":"Hydrogels with tunable stress relaxation regulate stem cell fate and activity","volume":"15","author":"Chaudhuri","year":"2016","journal-title":"Nat Mater"},{"key":"R3-20250513","first-page":"43","article-title":"3D printed scaffolds in endodontics:A review of the current status and future perspectives","volume":"46","author":"Derakhshanfar","year":"2020","journal-title":"J Endod"},{"key":"R4-20250513","first-page":"032001","article-title":"3D bioprinting of stem cells for dental applications:A state-of-the-art review","volume":"12","author":"Duarte Campos","year":"2020","journal-title":"Biofabrication"},{"key":"R5-20250513","first-page":"1260","article-title":"3D-printed bioceramic scaffolds with interconnected porous structures for enhanced bone regeneration","volume":"109","author":"Lin","year":"2021","journal-title":"J Biomed Mater Res A"},{"key":"R6-20250513","first-page":"155","article-title":"3D-printed bioceramic scaffolds with hierarchical porous structures for bone tissue engineering","volume":"136","author":"Fu","year":"2022","journal-title":"Acta Biomater"},{"key":"R7-20250513","first-page":"1321","article-title":"Additive manufacturing technologies for guided tissue and bone regeneration:A systematic review","volume":"98","author":"Rasperini","year":"2019","journal-title":"J Dent Res"},{"key":"R8-20250513","first-page":"112130","article-title":"3D printed porous scaffolds for bone regeneration:A review of current approaches and future perspectives","volume":"126","author":"Xiong","year":"2021","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"R9-20250513","first-page":"1135630","article-title":"3D printing and stem cells:The new frontier for periodontal regeneration","volume":"11","author":"Tumbarello","year":"2023","journal-title":"Front Bioeng Biotechnol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_12_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:53Z","timestamp":1787773433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_12_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":9,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_12_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-01-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}