{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:54Z","timestamp":1787071494932,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n \n To evaluate the clinical effectiveness of locally administered\n Satranidazole<\/jats:italic>\n gel and\n Aloe Vera<\/jats:italic>\n gel as adjunctive treatments to scaling and root planing (SRP) in the management of mild-to-moderate chronic periodontitis.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Forty-five participants were diagnosed with mild-to-moderate chronic periodontitis. Subjects were randomly assigned to one of three groups: SRP alone (control), SRP with\n Satranidazole<\/jats:italic>\n gel, and SRP with\n Aloe Vera<\/jats:italic>\n gel. Clinical parameters\u2014plaque index, gingival index, sulcus bleeding index, and probing pocket depth\u2014were assessed at baseline and one-month posttreatment. Statistical analysis used paired\n t<\/jats:italic>\n -tests, one-way ANOVA.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n All groups showed significant improvements in PI, GI, SBI, and PPD after one month (\n P<\/jats:italic>\n < 0.05). The combination of SRP with\n Satranidazole<\/jats:italic>\n and\n Aloe Vera<\/jats:italic>\n resulted in greater reductions in PI and PPD compared to SRP alone (\n P<\/jats:italic>\n < 0.05). The SRP with\n Satranidazole<\/jats:italic>\n group also had a superior reduction in SBI and PPD compared to the control group (\n P<\/jats:italic>\n < 0.05). No significant differences were found between the\n Satranidazole<\/jats:italic>\n and\n Aloe Vera<\/jats:italic>\n groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The use of\n Satranidazole<\/jats:italic>\n and\n Aloe Vera<\/jats:italic>\n gels as adjuncts to SRP significantly enhanced clinical parameters in comparison with SRP alone in the short term. While\n Satranidazole<\/jats:italic>\n offered slightly greater improvements in bleeding and pocket depth,\n Aloe Vera<\/jats:italic>\n presented a natural and cost-effective option.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1300_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:38Z","timestamp":1766044838000},"page":"S3217-S3219","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Satranidazole Gel and Aloe Vera Gel as Adjuncts to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Randomized, Single-Blind, Parallel-Group Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Aadarsh Vikram","family":"Dhan","sequence":"first","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroj","family":"Bagde","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Sharan","sequence":"additional","affiliation":[{"name":"Kasturi Clinic, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti Paryani","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Rungta College of Dental Sciences and Research, Bhilai, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.14219\/jada.archive.2000.0087","article-title":"Nonsurgical periodontal therapy in 2000: A literature review","volume":"131","author":"Greenstein","year":"2000","journal-title":"J Am Dent Assoc"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0757.1994.tb00022.x","article-title":"Antimicrobial strategies for treatment of periodontal diseases","volume":"5","author":"Goodson","year":"1994","journal-title":"Periodontol 2000"},{"key":"R4-20251218","first-page":"43","article-title":"A randomized controlled clinical trial on the clinical and microbiological efficacy of systemic satranidazole in the treatment of chronic periodontitis","volume":"15","author":"Pradeep","year":"2013","journal-title":"J Int Acad Periodontol"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4103\/0976-237X.161891","article-title":"Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial","volume":"6","author":"Priyanka","year":"2015","journal-title":"Contemp Clin Dent"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"47659","DOI":"10.1039\/C5RA02350E","article-title":"Mucoadhesive gel containing immunotherapeutic nanoparticulate satranidazole for treatment of periodontitis: Development and its clinical implications","volume":"5","author":"Singh","year":"2015","journal-title":"RSC Adv"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1902\/jop.2015.150161","article-title":"Adjunctive local delivery of aloe vera gel in patients with type 2 diabetes and chronic periodontitis: A randomized, controlled clinical trial","volume":"87","author":"Pradeep","year":"2016","journal-title":"J Periodontol"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/ayu.AYU_246_19","article-title":"Evaluation of aloe vera gel as a local drug delivery agent in the treatment of chronic periodontitis: A clinical and microbiological study","volume":"45","author":"Marella","year":"2024","journal-title":"AYU"},{"key":"R9-20251218","first-page":"49","article-title":"Efficacy of aloe vera gel as an adjunct to scaling and root planing in management of chronic localized moderate periodontitis: A randomized clinical trial","volume":"6","author":"Deepu","year":"2018","journal-title":"Int J Oral Care Res"},{"key":"R10-20251218","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.18203\/2320-6012.ijrms20181485","article-title":"Comparative evaluation of satranidazole and ornidazole effectiveness in the treatment of chronic periodontal diseases along with mechanical debridement","volume":"6","author":"Awasthi","year":"2018","journal-title":"Int J Res Med Sci"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1300_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:58Z","timestamp":1787068018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1300_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":10,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1300_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}