{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:26Z","timestamp":1787071466991,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Scaling and root planing (SRP) remains the gold standard for managing gingival and periodontal diseases. However, adjunctive therapies like ozone and microneedling have emerged as potential methods for enhancing clinical outcomes. This study aimed to evaluate the efficacy of combining microneedling with ozonated olive oil in patients with plaque-induced gingivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-five patients diagnosed with plaque-induced gingivitis were randomly assigned into three groups: Group 1 received SRP alone (control), Group 2 received SRP with microneedling, and Group 3 received SRP with microneedling plus ozonated olive oil. Clinical assessments, including Plaque Index (PI) and Gingival Index (GI), were recorded at baseline and after 15 days of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All three groups showed improvements in both the Plaque Index and Gingival Index. However, Group 3 (SRP with microneedling plus ozonated olive oil) exhibited the greatest reduction in both indices, with the results being statistically significant compared to the other two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The combination of microneedling and ozonated olive oil appears to be a highly effective, minimally invasive adjunct to SRP for managing plaque-induced gingivitis. This therapy demonstrated superior clinical outcomes in terms of plaque reduction and gingival inflammation compared to SRP alone or SRP with microneedling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1305_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:43Z","timestamp":1766044843000},"page":"S3220-S3222","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["To Evaluate the Efficacy of Ozonated Olive Oil with Microneedling for Gingival Inflammation\u2014A Clinical Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Aishwarya","family":"Duble","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implantology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroj","family":"Bagde","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Boddun","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Lohiya","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosheen","family":"Riza","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 world workshop on the classification of periodontal and peri\u2010implant diseases and conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J Periodontol"},{"issue":"Suppl 20","key":"R2-20251218","first-page":"S44","article-title":"Plaque-induced gingivitis: Case definition and diagnostic considerations","volume":"45","author":"Trombelli","year":"2018","journal-title":"J Clin Periodontol"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/cre2.618","article-title":"The effectiveness of microneedling technique using coconut and sesame oils on the severity of gingival inflammation and plaque accumulation: A randomized clinical trial","volume":"8","author":"Mostafa","year":"2022","journal-title":"Clin Exp Dent Res"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41405-019-0025-9","article-title":"Effectiveness of the adjunctive use of ozone and chlorhexidine in patients with chronic periodontitis","volume":"5","author":"Gandhi","year":"2019","journal-title":"BDJ Open"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5005\/jp-journals-10024-2516","article-title":"Efficacy of ozonized water and 0.2% chlorhexidine gluconate in the management of chronic periodontitis when used as an irrigant in conjugation with phase I therapy","volume":"20","author":"Kaur","year":"2019","journal-title":"J Contemp Dent Pract"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1399-302X.2004.00146.x","article-title":"Efficacy of ozone on survival and permeability of oral microorganisms","volume":"19","author":"Nagayoshi","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"177","DOI":"10.34172\/joddd.2023.40461","article-title":"Effect of 20-ppm ozone and 1% chlorhexidine gels on plaque index and Streptococcus mutans counts in the dental plaque in 6-12-year-old children: A randomized, double-blind clinical trial","volume":"17","author":"Adhami","year":"2023","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4103\/0972-124X.170806","article-title":"Effect of ozonated oil and chlorhexidine gel on plaque induced gingivitis: A randomized control clinical trial","volume":"20","author":"Indurkar","year":"2016","journal-title":"J Indian Soc Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1305_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:33Z","timestamp":1787067993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1305_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":8,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1305_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}