{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:36Z","timestamp":1787840676677,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontal diseases, initiated by microbial plaque biofilm, are inflammatory conditions affecting the supporting structures of teeth. Diabetes mellitus is a significant risk factor for periodontitis, and a bidirectional relationship exists where chronic periodontal inflammation may impair glycemic control. However, the impact of periodontal treatment on glycemic outcomes remains inconclusive. This study aimed to assess the effect of non-surgical periodontal therapy on metabolic control, as measured by HbA1c levels, in patients with type 2 diabetes and mild-to-moderate generalised chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A randomized controlled clinical trial was conducted at the Department of Periodontology, Manipal College of Dental Science, Manipal, Karnataka, India, with ethical clearance from the Institutional Ethics Committee (IEC No. 151\/2011). One hundred eligible participants, aged 30 to 70 years, diagnosed with type 2 diabetes (HbA1c 6.5-7.5%) and mild to moderate chronic periodontitis (clinical attachment loss [CAL] 1\u20134 mm per AAP 1999 classification), were recruited. Participants were randomized into two groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 50 each): a test group receiving non-surgical periodontal therapy (scaling and root planing) and a control group receiving no periodontal intervention. HbA1c levels were assessed at baseline and 3 months using high performance liquid chromatography. Clinical periodontal parameters (plaque index, gingival index, modified sulcus bleeding index, CAL, and probing pocket depth) were also assessed. Data were analysed using SPSS version 14, with paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests for within-group comparisons and independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests for intergroup differences, with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 considered statistically significant. Results and\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The test group showed greater improvements in all periodontal parameters compared to controls, though HbA1c levels did not differ significantly over three months. Overall, the findings indicate a modest link between better periodontal health and a slight HbA1c reduction in well-controlled diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1318_25","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:00:41Z","timestamp":1769158841000},"page":"S215-S217","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Periodontal Intervention on HbA1c Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Ruchi","family":"Raval","sequence":"first","affiliation":[{"name":"Department of Periodontology, K.M. Shah Dental College & Hospital, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalinga","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manipal College of Dental Sciences, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subraya Bhat","family":"Giliyar","sequence":"additional","affiliation":[{"name":"Preventive Dental Sciences Department (PDS), Division of Periodontics, College of Dental Surgery, Imam Abdulrahman bin Faizal University, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumari","family":"Upasana","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Govt. Dental College & Hospital, Rahui Nalanda, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Singh","sequence":"additional","affiliation":[{"name":"Chief Clinician, Dr Teeth Dental Clinic & Implant Centre, Gandhinagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayon","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Awadh Dental College & Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"R2-20260310","first-page":"1","article-title":"Papers","volume":"4","year":"1999","journal-title":"Ann Periodontol"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1902\/jop.1967.38.6_part2.610","article-title":"The gingival index, the plaque index and the retention index systems","volume":"38","author":"Loe","year":"1967","journal-title":"J Periodontol"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy. I. Prevalence and severity","volume":"21","author":"Loe","year":"1963","journal-title":"Acta Odontol Scand"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1399-302X.1987.tb00298.x","article-title":"The microbiota associated with successful or failing osseointegrated titanium implants","volume":"2","author":"Mombelli","year":"1987","journal-title":"Oral Microbiol Immunol"},{"key":"R6-20260310","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1600-051X.1986.tb01491.x","article-title":"Attachment level changes in destructive periodontal diseases","volume":"13","author":"Haffajee","year":"1986","journal-title":"J Clin Periodontol"},{"key":"R7-20260310","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-051X.1998.tb02417.x","article-title":"Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: Clinical, microbiological, and immunologic results","volume":"25","author":"Christgau","year":"1998","journal-title":"J Clin Periodontol"},{"key":"R8-20260310","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1600-051X.2005.00658.x","article-title":"The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus","volume":"32","author":"Kiran","year":"2005","journal-title":"J Clin Periodontol"},{"key":"R9-20260310","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7326\/0003-4819-151-12-200912150-00010","article-title":"The role of glycemia management in the prevention of cardiovascular disease\u2014starting over?","volume":"151","author":"Nathan","year":"2009","journal-title":"Ann Intern Med"},{"key":"R10-20260310","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-051X.1991.tb01121.x","article-title":"Immediate response to non-surgical periodontal treatment in subjects with diabetes mellitus","volume":"18","author":"Tervonen","year":"1991","journal-title":"J Clin Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1318_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:58Z","timestamp":1787837218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1318_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":10,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1318_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"2025-07-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}