{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:23Z","timestamp":1787071463726,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Oral cavity squamous cell carcinoma (OCSCC) and oropharyngeal squamous cell carcinoma (OPSCC) continue to pose major global health burdens, with conventional treatment modalities frequently associated with considerable morbidity. Emerging strategies such as neoadjuvant chemotherapy (NACT) for OCSCC and transoral robotic surgery (TORS) for OPSCC have been introduced to enhance personalization of care and preserve functional outcomes. This systematic review summarizes current evidence on the efficacy, safety and functional results of these modalities. Following PRISMA guidelines, a comprehensive search of major databases was conducted, and risk of bias was assessed for all eligible studies. The included literature evaluated key oncologic parameters such as overall survival, disease-free survival, recurrence rates and margin status, alongside patient-reported and clinician-reported functional measures including swallowing ability, speech outcomes and quality of life indices such as MD Anderson Dysphagia Inventory scores. Safety outcomes such as treatment-related toxicities, complication rates, and requirements for feeding tubes or tracheostomy were also analyzed. The review provides an integrated appraisal of the clinical utility of NACT in OCSCC and TORS in OPSCC, emphasizing their potential to improve oncologic control while minimizing functional impairment, while also addressing the influence of study quality and methodological limitations on the strength of the available evidence.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1320_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:09Z","timestamp":1766044809000},"page":"S2855-S2858","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Treatment Strategies for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma: A Systematic Review of Neoadjuvant Chemotherapy and Transoral Robotic Surgery"],"prefix":"10.4103","volume":"17","author":[{"given":"R. Manthru","family":"Naik","sequence":"first","affiliation":[{"name":"Department of Dentistry, Government Medical College, Suryapet, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Mynam","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Government Medical College, Sangareddy, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Barman","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Evergreen Superspeciality Clinic, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. G.","family":"Srichakra","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parthiban","family":"Saket","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Sri Venkateswaraa Dental College, Villianur, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Evergreen Superspeciality Clinic, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandisha","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Surendera Dental College, Ganganagar, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","first-page":"414","article-title":"Quality of life of patients with oral squamous cell carcinoma","volume":"53","author":"Markovic","year":"2024","journal-title":"Iran J Public Health"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"1444326","DOI":"10.3389\/fonc.2024.1444326","article-title":"Evolving trends in oral cancer burden in Europe: A systematic review","volume":"14","author":"Ghanem","year":"2024","journal-title":"Front Oncol"},{"key":"R3-20251218","first-page":"42","article-title":"Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma","volume":"11","author":"Barsouk","year":"2023","journal-title":"Int J Med Sci"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1200\/JCO.21.00179","article-title":"Prospective phase II open-label randomized controlled trial to compare mandibular preservation in upfront surgery with neoadjuvant chemotherapy followed by surgery in operable oral cavity cancer","volume":"40","author":"Chaukar","year":"2022","journal-title":"J Clin Oncol"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1001\/archotol.133.10.1044","article-title":"Transoral carbon dioxide laser supraglottic laryngectomy and irradiation in stage I, II, and III squamous cell carcinoma of the supraglottic larynx: Report of southwest oncology group phase 2 trial S9709","volume":"133","author":"Agrawal","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1007\/s00405-022-07333-7","article-title":"Cytology-based cancer surgery of the head and neck (CyCaS-HN): A prospective, randomized, controlled clinical trial","volume":"279","author":"Linxweiler","year":"2022","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1200\/JCO.24.00119","article-title":"Radiotherapy versus transoral robotic surgery for oropharyngeal squamous cell carcinoma: Final results of the ORATOR randomized trial","volume":"42","author":"Nichols","year":"2024","journal-title":"J Clin Oncol"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1080\/00016489.2023.2269998","article-title":"The effect of dexamethasone on functional pain following Transoral Robotic Surgery: A randomized double blinded clinical trial","volume":"143","author":"Larsen","year":"2023","journal-title":"Acta Oto-Laryngologica"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1320_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:29Z","timestamp":1787067989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1320_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":8,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1320_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}