{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:43Z","timestamp":1787840803925,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n \n Secondary caries at the restorative margins is the common reason for dental composite restoration failure. Our objectives were to evaluate the anti-caries activity of new generation rechargeable composites and to evaluate three different concentrations of quaternary ammonium methacrylate compound on\n S. mutans<\/jats:italic>\n biofilm.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n The composite resin consisted of urethane dimethacrylate and triethylene glycol divinylbenzyl ether and was prepared with 2%, 5%, and 8% of dimethylaminohexadecyl methacrylate (DMAHDM) and 20% of nanoparticles of amorphous calcium phosphate for remineralization.<\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n \n It was found that the incorporation of 8% DMAHDM significantly reduced\n S. mutans<\/jats:italic>\n biofilm colony-forming units by 2\u20135 log by 7 folds, compared to the composite with 2% DMAHDM (\n P<\/jats:italic>\n < 0.05) and nonsignificantly to 5% group. Adding 5% DMAHDM provides sustained Ca and P ion release as compared to 2% and 8% groups.\n <\/jats:p>\n <\/jats:sec>\n \n Concusion:<\/jats:title>\n Hence, it was concluded that the composite with DMAHDM content increased the antibacterial effect in a dose-dependent manner and provided sustained Ca and P ion release till 70 days.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1334_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:06:32Z","timestamp":1738235192000},"page":"S4578-S4580","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Anti-Caries Activity of New Generation Rechargeable Dental Composites \u2013 An In Vitro Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Anjali","family":"Savita","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, People\u2019s Dental Academy, People\u2019s University, Bhanpur, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashvi","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, People\u2019s Dental Academy, People\u2019s University, Bhanpur, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vertika","family":"Dubey","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgeon, Dubey Dental Clinic and Implant Center, Kolar Road, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, People\u2019s College of Dental Sciences, People\u2019s University, Bhanpur, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Najam","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, People\u2019s College of Dental Sciences, People\u2019s University, Bhanpur, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinkal","family":"Luhana","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, People\u2019s Dental Academy, People\u2019s University, Bhanpur, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"103541","DOI":"10.1016\/j.jdent.2020.103541","article-title":"Secondary caries risk of different adhesive strategies and restorative materials in permanent teeth:Systematic review and network meta-analysis","volume":"104","author":"Askar","year":"2021","journal-title":"J Dent"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.dental.2015.11.015","article-title":"Novel rechargeable calcium phosphate dental nanocomposite","volume":"32","author":"Zhang","year":"2016","journal-title":"Dent Mater"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jdsr.2021.03.003","article-title":"A comprehensive review of the antibacterial activity of dimethylaminohexadecyl methacrylate (DMAHDM) and its influence on mechanical properties of resin-based dental materials","volume":"57","author":"de","year":"2021","journal-title":"Jpn Dent Sci Rev"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"103406","DOI":"10.1016\/j.jdent.2020.103406","article-title":"Novel low-shrinkage-stress nanocomposite with remineralization and antibacterial abilities to protect marginal enamel under biofilm","volume":"99","author":"Bhadila","year":"2020","journal-title":"J Dent"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.dental.2011.10.004","article-title":"Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications","volume":"28","author":"Antonucci","year":"2012","journal-title":"Dent Mater"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jdent.2018.03.003","article-title":"Novel rechargeable calcium phosphate nanocomposite with antibacterial activity to suppress biofilm acids and dental caries","volume":"72","author":"Al-Dulaijan","year":"2018","journal-title":"J Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1334_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:20Z","timestamp":1787837360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1334_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":6,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1334_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-09-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}