{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:54Z","timestamp":1787071494640,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intrabony defects in periodontal diseases create a serious problem in periodontal treatment, and regenerative procedure is usually used to achieve the best result. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are platelet concentrates of autologous origin that has been extensively studied in its capacity to hasten soft and hard tissue regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In a randomized controlled clinical trial using 30 patients with chronic periodontitis, having at least one intrabony defect, the treatment was conducted targeting the presence of an intrabony defect surface at the site of delivery. Patients were randomly separated into two categories: Group A meant PRF with open flap debridement, and Group B meant PRP with open flap debridement. Clinical measurements, such as probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD), were followed at baseline, three months, and six months postoperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both groups had great results in changes in clinical parameters as compared to baseline to six months. The mean PPD reduction (4.1 0.5 mm) and CAL gain (3.6 0.4 mm) in group (PRF) were higher than the reduction in PPD (3.4 0.6 mm) and gain in CAL (2.8 0.5 mm) in group (PRP). The fill with radiographic defect was greater in PRF (62%) when compared to PRP (49%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PRF and PRP are practical in intrabony periodontal defects treatment. Nevertheless, PRF had better clinical and radiographic results because it released growth factors more slowly and could easily be prepared.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1341_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:01:23Z","timestamp":1766044883000},"page":"S3253-S3255","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Analysis of Platelet-Rich Fibrin (PRF) and Platelet-Rich Plasma (PRP) in the Treatment of Intrabony Periodontal Defects"],"prefix":"10.4103","volume":"17","author":[{"given":"Rebecca","family":"Chowdhry","sequence":"first","affiliation":[{"name":"Department of Periodontics, ITS Dental College, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, ITS Dental College, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Nautiyal","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kalka Dental College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jansiya","family":"Thangavelu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Vinayaka Mission\u2019s Sankarachariyar Dental college and Vinayaka Mission Research Foundation (Deemed to be University), Salem, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheswari","family":"Eluru","sequence":"additional","affiliation":[{"name":"Lakewood Family Dental, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1902\/jop.2012.110705","article-title":"Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: A randomized controlled clinical trial","volume":"83","author":"Pradeep","year":"2012","journal-title":"J Periodontol"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1902\/jop.2011.110075","article-title":"Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: A randomized controlled 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autologous platelet-rich fibrin in the treatment of intra-bony defects: A controlled clinical trial","volume":"38","author":"Thorat","year":"2011","journal-title":"J Clin Periodontol"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1902\/jop.2015.140646","article-title":"Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial","volume":"86","author":"Pradeep","year":"2015","journal-title":"J Periodontol"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1600-0765.2011.01446.x","article-title":"Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects","volume":"47","author":"Lekovic","year":"2012","journal-title":"J Periodontal Res"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/00016357.2015.1035672","article-title":"Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: A randomized split mouth clinical trial","volume":"74","author":"Agarwal","year":"2016","journal-title":"Acta Odontol Scand"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1341_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:58Z","timestamp":1787068018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1341_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":8,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1341_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}