{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:39Z","timestamp":1787840559811,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of the research was to ascertain whether serum levels of the biochemical markers adiponectin and leptin are related to clinical periodontal characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Method:<\/jats:title>\n                    <jats:p>For the study, 20 people with chronic periodontitis (Group A) and 20 healthy people (Group B) were enrolled. Assessments were conducted on periodontal markers, including bleeding on probing (POP), gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL). An enzyme-linked immunosorbent assay (ELISA) test was used to assess the levels of adiponectin and leptin in serum samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>There was significant elevation in average level of leptin in chronic periodontitis in association to that in healthy group. On the other hand, there was considerable decrease in serum adiponectin in group A in association to healthy group. The ratio of leptin\\adiponectin was appreciably greater amongst periodontitis group compared to healthy group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The current investigation leads us to the conclusion that the pathophysiology of periodontitis is significantly influenced by serum levels of adiponectin and leptin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1355_24","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:03:55Z","timestamp":1731481435000},"page":"S3887-S3889","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Serum Adiponectin and Leptin in Chronic Periodontitis Over Healthy Individuals"],"prefix":"10.4103","volume":"16","author":[{"given":"Reghunathan S.","family":"Preethanath","sequence":"first","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaroop","family":"Chandy","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Annoor Dental College, Muvatupuzha, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubesh Khan","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry, College of Dentistry, Qassim University, Al-Qassim, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bugude Shiva","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Applied Medical Sciences, Qassim University, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavithra Rangarajan","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Ragas Dental College and Hospital, Uthandi, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Narayane","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K. Saraswathi","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventative Dentistry, C K S Teja Institute of Dental Sciences and Research, Tirupati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12903-017-0395-0","article-title":"Association of circulating leptin and adiponectin with periodontitis:A systematic review and meta-analysis","volume":"17","author":"Zhu","year":"2017","journal-title":"BMC Oral Health"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"e380","DOI":"10.4317\/jced.52350","article-title":"Adiponectin, leptin and TNF-\u03b1 serum levels in obese and normal weight Peruvian adults with and without chronic periodontitis","volume":"7","author":"Mendoza-Azpur","year":"2015","journal-title":"J Clin Exp Dent"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.4103\/ccd.ccd_1_18","article-title":"Evaluation of serum leptin and adiponectin in obese individuals with chronic periodontitis","volume":"9","author":"Boyapati","year":"2018","journal-title":"Contemp Clin Dent"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/952636","article-title":"Serum ratio of leptin to adiponectin in patients with chronic periodontitis and type 2 diabetes mellitus","author":"Ling","year":"2014","journal-title":"ISRN Biomarkers"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1902\/jop.2012.120254","article-title":"Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis","volume":"84","author":"Zimmermann","year":"2012","journal-title":"J Periodontol"},{"key":"R6-20241227","first-page":"63","article-title":"Evaluation of serum leptin and adiponectin levels in Iraqi patients with chronic periodontitis","volume":"14","author":"Ali Al-Azawy","year":"2015","journal-title":"IOSR J Dent Med Sci"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1355_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:03Z","timestamp":1787837103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1355_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":6,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1355_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"2024-09-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}