{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:49:38Z","timestamp":1790509778740,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate and compare the sealing ability of Mineral Trioxide Aggregate, Biodentine, and bioceramic based root repair material Bio-C Repair when used as a furcation perforation repair material.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      In the present study 30 human lower first molars were used. Collected teeth had no caries or restoration, and none had fused roots. Every molar had an endodontic access cavity made utilizing a high-speed long\u2014shank round bur for the initial entry and an Endo\u2014Z for lateral extension and finishing the cavity walls. Each canal orifice was covered with a temporary filling material. The pulpal floor and cavity walls of every molar were thoroughly quoted with two successive coats of clear nail polish. A significant perforation was made between the orifices to the formation area using high speed, long shank round bur #4. The perforation centered between the medial and distal orifice. They were divided into three experimental groups:- Group I: 10 molars repaired using MTA, Group II: 10 molars repaired using Biodentine, Group III: 10 molars repaired using Bio C Repair. Moist cotton pellets were placed over the repair materials, and molars were kept in 100% humidity for 24 h to allow materials to set and later nail varnish was applied to all. Then, according to each group, molars were put in Petri dishes. Methylene blue dye was applied inside the access cavity of all samples for 24 h. Molars were placed under running tap water for 30 min to remove all residues of methylene blue, and then varnish was removed with a Parker blade #15 and polishing discs. Molars were placed in vials containing 1 mL of concentrated (65 wt%) nitric acid for 3 days. Vials were centrifuged at 14,000 rpm for 5 min. The supernatant from each sample was transferred in a quantity of 200 L to a 96-well plate. Sample absorbance was read by an automatic microplate spectrophotometer at 550 nm using concentrated nitric acid as a blank. Statistical analysis was performed using one-way analysis of variance. When the analysis of variance test was significant, the pairwise comparison of the means was done using a\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      test. The significance level was set at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05. Statistical analysis was performed with SPSS 14.0 (SPSS Inc., Chicago, IL, USA) for Windows (Microsoft, Redmond, WA, USA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean microleakage seen in Group I: 1.56, Group II: 1.23, Group III: 1.48. Intergroup comparison between Group I, Group II, Group III showed statistically significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Within the limitations of the study, it can be concluded that Biodentine showed maximum sealing ability followed by BIO-C and then MTA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1376_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:01:04Z","timestamp":1766044864000},"page":"S3295-S3297","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Spectrophotometric Analysis of Sealing Ability of MTA, Biodentine, and Bio C Used for Furcal Perforations\u2014An in vitro Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Sathish","family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SMBT Dental College and Hospital, Sangamner, Ahmednagar, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitija M.","family":"Diggikar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SMBT Dental College and Hospital, Sangamner, Ahmednagar, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradnya","family":"Nagmode","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SMBT Dental College and Hospital, Sangamner, Ahmednagar, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Lokhande","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SMBT Dental College and Hospital, Sangamner, Ahmednagar, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnavi A.","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SMBT Dental College and Hospital, Sangamner, Ahmednagar, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0030-4220(67)90547-6","article-title":"Endodontic failures \u2013 An analysis based on clinical, roentgenographic, and histologic findings. II","volume":"23","author":"Seltzer","year":"1967","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0030-4220(82)90427-3","article-title":"A histologic evaluation of periodontal tissues adjacent to root perforations filled with Cavit","volume":"54","author":"Jew","year":"1982","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/0103-6440201702451","article-title":"Common operative procedural errors and clinical factors associated with root canal treatment","volume":"28","author":"Estrela","year":"2017","journal-title":"Braz Dent J"},{"key":"R4-20251218","first-page":"89","article-title":"Fully injectable calcium phosphate cement \u2013 A promise to dentistry","volume":"15","author":"Komath","year":"2004","journal-title":"Indian J Dent Res"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1079-2104(96)80382-9","article-title":"Repair of furcal perforations with mineral trioxide aggregate: Two case reports","volume":"82","author":"Arens","year":"1996","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00004770-200402000-00004","article-title":"Repair of root perforations using mineral trioxide aggregate: A long-term study","volume":"30","author":"Main","year":"2004","journal-title":"J Endod"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00004770-200206000-00013","article-title":"Sealing ability of mineral trioxide aggregate and super-EBA when used as furcation repair materials: A longitudinal study","volume":"28","author":"Weldon","year":"2002","journal-title":"J Endod"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"160951","DOI":"10.1155\/2014\/160951","article-title":"A review on biodentine, a contemporary dentine replacement and repair material","volume":"2014","author":"Malkondu","year":"2014","journal-title":"Biomed Res Int"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/0103-6440201902457","article-title":"Cytotoxicity, biocompatibility and biomineralization of a new ready-for-use bioceramic repair material","volume":"30","author":"Benetti","year":"2019","journal-title":"Braz Dent J"},{"key":"R10-20251218","first-page":"1","article-title":"Bioinorganics in bioactive calcium silicate ceramics for bone tissue repair: bioactivity and biological properties","volume":"5","author":"Mohammadi","year":"2014","journal-title":"J Ceram Sci Technol"},{"key":"R11-20251218","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1601-1546.2006.00213.x","article-title":"Diagnosis and treatment of accidental root perforations","volume":"13","author":"Tsesis","year":"2006","journal-title":"Endodontic Topics"},{"key":"R12-20251218","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/j.tripleo.2006.09.007","article-title":"Histological evaluation of contaminated furcal perforation in dogs\u2019 teeth repaired by MTA with or without internal matrix","volume":"103","author":"Al-Daafas","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R13-20251218","first-page":"467","article-title":"Root perforation repair: Surgical and nonsurgical management","volume":"13","author":"Roda","year":"2001","journal-title":"Pract Proced Aesthet Dent"},{"key":"R14-20251218","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-9657.1996.tb00524.x","article-title":"Root perforations: Classification and treatment choices based on prognostic factors","volume":"12","author":"Fuss","year":"1996","journal-title":"Endod Dent Traumatol"},{"key":"R15-20251218","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.joen.2007.07.024","article-title":"The ability of Portland cement, MTA, and MTA Bio to prevent through-and-through fluid movement in repaired furcal perforations","volume":"33","author":"De-Deus","year":"2007","journal-title":"J Endod"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1376_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:44Z","timestamp":1787068004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1376_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":15,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1376_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}