{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:27:17Z","timestamp":1787776037894,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Surgical site infections (SSIs) are among the most common postoperative complications, significantly impacting morbidity, hospital stay, and healthcare costs. Identifying the microbiological spectrum and resistance patterns is essential for effective management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>This prospective observational study was conducted in a tertiary care hospital in Central India among 78 patients who developed SSIs following elective neurosurgical and laparotomy procedures. Pus\/wound swab samples were collected aseptically and processed using standard culture methods. Isolates were identified, and antibiotic susceptibility testing was performed as per CLSI guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 78 samples, 62.8% showed growth.\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      (21.8%) and\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      (19.2%) were the most common isolates. Concomitant infections included UTI (46.5%), BSI (51.2%), and VAP (7%).\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      showed 82.3% sensitivity to piperacillin-tazobactam and 53% to amikacin.\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      was 100% sensitive to vancomycin and linezolid. Klebsiella and Pseudomonas showed 75% and 42.8% sensitivity to piperacillin-tazobactam, respectively. Acinetobacter showed 50% sensitivity to meropenem.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Gram-negative organisms, particularly\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      and Klebsiella, were the leading SSI pathogens, with significant resistance to cephalosporins and carbapenems. The high MRSA prevalence highlights the need for stringent infection control and targeted antibiotic stewardship.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1379_25","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:01:34Z","timestamp":1768226494000},"page":"S221-S223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Microbiological Profile of Surgical Site Infections Post Laparotomy and Neurosurgery: A Prospective Observational Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Ashish","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Microbiology, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suryakant","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of ENT, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Microbiology, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeevan","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purti","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra S.","family":"Rajput","sequence":"additional","affiliation":[{"name":"Department of Microbiology, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"322","DOI":"10.18231\/j.ijmr.2020.057","article-title":"Spectrum of surgical site infections at a tertiary care hospital in Hyderabad","volume":"7","author":"Muqtadir","year":"2020","journal-title":"Indian J Microbiol Res"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"71","DOI":"10.18231\/2394-5478.2019.0015","article-title":"Antimicrobial susceptibility pattern of organisms causing surgical site infection in a tertiary care hospital, Valsad, South Gujarat","volume":"6","author":"Patel","year":"2019","journal-title":"Indian J Microbiol Res"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"336","DOI":"10.18231\/j.ijmr.2024.057","article-title":"Antibiotic-resistance profile of bacteria isolated from patients with surgical site infections: Study at rural-based tertiary hospital","volume":"11","author":"Bhalodia","year":"2024","journal-title":"Indian J Microbiol Res"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"962","DOI":"10.6026\/97320630018962","article-title":"Clinical and bacteriological profile of abdominal surgical site infections in an Indian Hospital","volume":"18","author":"Ratnesh","year":"2022","journal-title":"Bioinformation"},{"key":"R5-20260310","first-page":"157","article-title":"Bacteriological profile and antibiotic susceptibility pattern of surgical site infections at a tertiary care centre in South Kerala","volume":"32","author":"Poornima","year":"2025","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"R6-20260310","doi-asserted-by":"crossref","first-page":"25","DOI":"10.18231\/j.ijmr.2024.005","article-title":"A study on clinico-demographic and microbiological profile of surgical site infection in a tertiary care hospital, Kolkata: An alarming trend","volume":"11","author":"Banik","year":"2024","journal-title":"Indian J Microbiol Res"},{"key":"R7-20260310","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ajic.2014.10.002","article-title":"A 4-year prospective study to determine the incidence and microbial etiology of surgical site infections at a private tertiary care hospital in Mumbai, India","volume":"43","author":"Shah","year":"2015","journal-title":"Am J Infect Control"},{"key":"R8-20260310","doi-asserted-by":"crossref","first-page":"76","DOI":"10.18231\/j.ijmr.2021.016","article-title":"Bacteriological profile and antibiotic susceptibility patterns of wound infections in a tertiary care hospital in South India","volume":"8","author":"Roopashree","year":"2021","journal-title":"Indian J Microbiol Res"},{"key":"R9-20260310","doi-asserted-by":"crossref","first-page":"000662","DOI":"10.1099\/acmi.0.000662.v4","article-title":"Genotyping of Acinetobacter baumannii isolates from a tertiary care hospital in Cochin, South India","volume":"5","author":"Rajan","year":"2023","journal-title":"Access Microbiol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1379_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:48:50Z","timestamp":1787773730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1379_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 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