{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:20Z","timestamp":1786653680784,"version":"build-2736575974"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Periodontal diseases are multifactorial, influenced by genetic predisposition, environmental factors, and clinical conditions. Current treatment strategies largely rely on standardized protocols, often failing to account for individual patient differences. This study explores the potential of personalized periodontal treatments that integrate genetic, environmental, and clinical data to optimize therapeutic outcomes. A cohort of 150 patients with various stages of periodontal disease underwent tailored treatments based on genetic screening, lifestyle factors, and clinical presentation. Statistical analyses revealed significant improvements in clinical outcomes for those receiving personalized treatments compared to the control group receiving standard care, demonstrating the efficacy of personalized treatment approaches in managing periodontal disease.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1435_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:04:54Z","timestamp":1735257894000},"page":"S4088-S4090","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Development of Personalized Periodontal Treatment Approaches: Integration of Genetic, Environmental, and Clinical Factors"],"prefix":"10.4103","volume":"16","author":[{"given":"Rajneesh","family":"Maheshwari","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implatology, ITS-CDSR Muradnagar, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kalka Dental College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Zeba","sequence":"additional","affiliation":[{"name":"Consultant Oral Radiologist, Department of Oral Medicine and Diagnostic Radiology, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Kalka Dental College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, ITS-CDSR Muradnagar Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashansa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, ITS-CDSR Muradnagar Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"issue":"8 Suppl","key":"R1-20241227","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1902\/jop.2008.080220","article-title":"Rethinking periodontal inflammation","volume":"79","author":"Offenbacher","year":"2008","journal-title":"J Periodontol"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-051X.1997.tb01187.x","article-title":"The interleukin-1 genotype as a severity factor in adult periodontal disease","volume":"24","author":"Kornman","year":"1997","journal-title":"J Clin Periodontol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0757.2005.00118.x","article-title":"The genetic basis of periodontitis","volume":"39","author":"Kinane","year":"2005","journal-title":"Periodontol 2000"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/154405910308200202","article-title":"Resolution of inflammation:A new paradigm for the pathogenesis of periodontal diseases","volume":"82","author":"Van Dyke","year":"2003","journal-title":"J Dent Res"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"64","author":"Cekici","year":"2014","journal-title":"Periodontol 2000"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1435_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:54Z","timestamp":1786650054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1435_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":5,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1435_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-10-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}